Cargando…

Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide

BACKGROUND: Brain amyloid deposition is one of the main pathological characteristics of Alzheimer’s disease (AD). Soluble oligomers formed during the process that causes β-amyloid (Aβ) to aggregate into plaques are considered to have major neurotoxicity. Currently, drug development for the treatment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jian-Xiang, Lai, Yi-Hui, Mi, Pan-Ying, Dai, Xue-Ling, Zhang, Ran, Zhang, Zhan-Jun, Zhang, Shu-Juan, Zhang, Xi-Wen, Zhang, Xi-Yan, Yang, Bing-Yu, Cui, Dong-Mei, Zhang, Chen, Zhao, Chang-Qi, Dou, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918606/ https://www.ncbi.nlm.nih.gov/pubmed/31847879 http://dx.doi.org/10.1186/s13195-019-0560-6

Ejemplares similares

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
por: Kim, Hye Yun, et al.
Publicado: (2015)

Corrigendum: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
por: Kim, Hye Yun, et al.
Publicado: (2016)

Autophagic Degradation Deficit Involved in Sevoflurane-Induced Amyloid Pathology and Spatial Learning Impairment in APP/PS1 Transgenic Mice
por: Geng, Pengcheng, et al.
Publicado: (2018)

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
por: Killick, Richard, et al.
Publicado: (2009)

Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction
por: Yang, Cuicui, et al.
Publicado: (2020)

Bis(9)-(−)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice
por: Shi, Yuhuan, et al.
Publicado: (2018)

Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice
por: Jiang, Rong, et al.
Publicado: (2020)

VIP Enhances Phagocytosis of Fibrillar Beta-Amyloid by Microglia and Attenuates Amyloid Deposition in the Brain of APP/PS1 Mice
por: Song, Min, et al.
Publicado: (2012)

Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice
por: Wang, Xiao-feng, et al.
Publicado: (2021)

Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice
por: Cai, Haobin, et al.
Publicado: (2017)

Pan-PPAR Modulation Effectively Protects APP/PS1 Mice from Amyloid Deposition and Cognitive Deficits
por: Kummer, Markus P., et al.
Publicado: (2014)

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis
por: Lin, Kaili, et al.
Publicado: (2021)

DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease
por: Sha, Sha, et al.
Publicado: (2022)

Correction: Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice
por: Cai, Haobin, et al.
Publicado: (2018)

Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice
por: Shi, Jing, et al.
Publicado: (2023)

Assembly Mechanism for Aggregation of Amyloid Fibrils
por: Zhang, Lingyun
Publicado: (2018)

Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing
por: Hu, Tao, et al.
Publicado: (2017)

Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice
por: Zhang, Shuai, et al.
Publicado: (2017)

Short Peptides as Inhibitors of Amyloid Aggregation
por: Neddenriep, Bradley, et al.
Publicado: (2011)

Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions
por: Qiao, Ou, et al.
Publicado: (2021)

Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
por: Yang, Yunjie, et al.
Publicado: (2020)

Dynamic Changes in the Levels of Amyloid-β(42) Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer’s Disease
por: Zhang, Liding, et al.
Publicado: (2021)

SRC-1 Knockout Exerts No Effect on Amyloid β Deposition in APP/PS1 Mice
por: Wu, Qiong, et al.
Publicado: (2020)

On the Conformational Dynamics of β-Amyloid Forming Peptides: A Computational Perspective
por: Saravanan, Konda Mani, et al.
Publicado: (2020)

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice
por: Wang, Sheng, et al.
Publicado: (2019)

Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease
por: Zhao, Yue, et al.
Publicado: (2020)

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
por: Zhang, Xiaojie, et al.
Publicado: (2013)

Food protein-derived amyloids do not accelerate amyloid β aggregation
por: Rahman, M. Mahafuzur, et al.
Publicado: (2023)

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation
por: Pilkington, Emily H., et al.
Publicado: (2017)

Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice
por: Yang, Xiao-bo, et al.
Publicado: (2022)

Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice
por: Chen, Yanxing, et al.
Publicado: (2021)

Intranasal “painless” Human Nerve Growth Factors Slows Amyloid Neurodegeneration and Prevents Memory Deficits in App X PS1 Mice
por: Capsoni, Simona, et al.
Publicado: (2012)

The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model
por: Forest, Kelly H., et al.
Publicado: (2021)

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR
por: Sepkhanova, I., et al.
Publicado: (2009)

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides
por: Huang, Yaliang, et al.
Publicado: (2021)

Key Residue for Aggregation of Amyloid-β Peptides
por: Itoh, Satoru G., et al.
Publicado: (2022)

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
por: Ruiz-Riquelme, Alejandro, et al.
Publicado: (2018)

Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice
por: Hu, Wei-Hui, et al.
Publicado: (2020)

A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway
por: Han, Ying, et al.
Publicado: (2022)

Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
por: Li, Yuanyuan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_m7nnv6351shiqrneak1ei6noho