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SPAR – a randomised, placebo-controlled phase II trial of simvastatin in addition to standard chemotherapy and radiation in preoperative treatment for rectal cancer: an AGITG clinical trial

BACKGROUND: Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression fo...

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Detalles Bibliográficos
Autores principales:	Jameson, Michael B., Gormly, Kirsten, Espinoza, David, Hague, Wendy, Asghari, Gholamreza, Jeffery, Grahame Mark, Price, Timothy Jay, Karapetis, Christos Stelios, Arendse, Michael, Armstrong, James, Childs, John, Frizelle, Frank A., Ngan, Sam, Stevenson, Andrew, Oostendorp, Martinus, Ackland, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918635/ https://www.ncbi.nlm.nih.gov/pubmed/31847830 http://dx.doi.org/10.1186/s12885-019-6405-7

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