Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display

Tumor-infiltrating lymphocytes (TIL) are considered enriched for T cells recognizing shared tumor antigens or mutation-derived neoepitopes. We performed exome sequencing and HLA-A(*)02:01 epitope prediction from tumor cell lines from two HLA-A2-positive melanoma patients whose TIL displayed strong t...

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Detalles Bibliográficos
Autores principales: Wickström, Stina L., Lövgren, Tanja, Volkmar, Michael, Reinhold, Bruce, Duke-Cohan, Jonathan S., Hartmann, Laura, Rebmann, Janina, Mueller, Anja, Melief, Jeroen, Maas, Roeltje, Ligtenberg, Maarten, Hansson, Johan, Offringa, Rienk, Seliger, Barbara, Poschke, Isabel, Reinherz, Ellis L., Kiessling, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918724/
https://www.ncbi.nlm.nih.gov/pubmed/31921104
http://dx.doi.org/10.3389/fimmu.2019.02766

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