Cargando…

Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration

Recently developed therapeutic approaches for the treatment of Huntington's disease (HD) require preclinical testing in large animal models. The minipig is a suitable experimental animal because of its large gyrencephalic brain, body weight of 70-100 kg, long lifespan, and anatomical, physiolog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ardan, Taras, Baxa, Monika, Levinská, Božena, Sedláčková, Miroslava, Nguyen, The Duong, Klíma, Jiří, Juhás, Štefan, Juhásová, Jana, Šmatlíková, Petra, Vochozková, Petra, Motlík, Jan, Ellederová, Zdenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918760/ https://www.ncbi.nlm.nih.gov/pubmed/31645369 http://dx.doi.org/10.1242/dmm.041319

Ejemplares similares

Longitudinal study revealing motor, cognitive and behavioral decline in a transgenic minipig model of Huntington's disease
por: Baxa, Monika, et al.
Publicado: (2019)

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
por: Askeland, Georgina, et al.
Publicado: (2018)

Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease
por: Rodinova, Marie, et al.
Publicado: (2019)

AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model
por: Evers, Melvin M., et al.
Publicado: (2018)

Subretinal Implantation of Human Primary RPE Cells Cultured on Nanofibrous Membranes in Minipigs
por: Lytvynchuk, Lyubomyr, et al.
Publicado: (2022)

Advancement in Nanostructure-Based Tissue-Engineered Biomaterials for Retinal Degenerative Diseases
por: Rohiwal, Sonali Suresh, et al.
Publicado: (2021)

Behavioral testing of minipigs transgenic for the Huntington gene—A three-year observational study
por: Schuldenzucker, Verena, et al.
Publicado: (2017)

Mitochondrial Dysfunction in a High Intraocular Pressure-Induced Retinal Ischemia Minipig Model
por: Pasák, Michael, et al.
Publicado: (2022)

Development of an AAV-Based MicroRNA Gene Therapy to Treat Machado-Joseph Disease
por: Martier, Raygene, et al.
Publicado: (2019)

Large Animal Models of Huntington’s Disease: What We Have Learned and Where We Need to Go Next
por: Howland, David, et al.
Publicado: (2020)

Glycation potentiates neurodegeneration in models of Huntington’s disease
por: Vicente Miranda, Hugo, et al.
Publicado: (2016)

Isolation and Characterization of Small Extracellular Vesicles from Porcine Blood Plasma, Cerebrospinal Fluid, and Seminal Plasma
por: Kupcova Skalnikova, Helena, et al.
Publicado: (2019)

Huntingtin Co-Isolates with Small Extracellular Vesicles from Blood Plasma of TgHD and KI-HD Pig Models of Huntington’s Disease and Human Blood Plasma
por: Ananbeh, Hanadi, et al.
Publicado: (2022)

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
por: Margulis, Julia, et al.
Publicado: (2014)

No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs
por: Kleinbongard, Petra, et al.
Publicado: (2023)

Gradual Increase in Environmental Light Intensity Induces Oxidative Stress and Inflammation and Accelerates Retinal Neurodegeneration
por: Kutsyr, Oksana, et al.
Publicado: (2020)

Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes
por: Grotz, Sophia, et al.
Publicado: (2022)

Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease
por: Tamura, Takuya, et al.
Publicado: (2011)

Ribosome traffic jam in neurodegeneration: decoding hurdles in Huntington disease
por: Subramaniam, Srinivasa
Publicado: (2021)

Gradual Rewarming with Gradual Increase in Pressure during Machine Perfusion after Cold Static Preservation Reduces Kidney Ischemia Reperfusion Injury
por: Mahboub, Paria, et al.
Publicado: (2015)

Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity
por: Kakinohana, Osamu, et al.
Publicado: (2012)

Correction: Gradual Rewarming with Gradual Increase in Pressure during Machine Perfusion after Cold Static Preservation Reduces Kidney Ischemia Reperfusion Injury
por: Mahboub, Paria, et al.
Publicado: (2016)

Correction: Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease
por: Tamura, Takuya, et al.
Publicado: (2012)

Prodromal Huntington Disease as a Model for Functional Compensation of Early Neurodegeneration
por: Malejko, Kathrin, et al.
Publicado: (2014)

Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
por: Flores-Hernández, Jorge, et al.
Publicado: (2018)

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease
por: Liu, Chunyue, et al.
Publicado: (2022)

Single loop-and-clips technique (KING closure) for gastrotomy closure after transgastric ovariectomy: a survival experiment
por: Ryska, Ondrej, et al.
Publicado: (2012)

The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues
por: Berthelsen, Martin Fogtmann, et al.
Publicado: (2021)

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration
por: De Luca, Gabriele, et al.
Publicado: (2008)

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
por: Ju, Tz-Chuen, et al.
Publicado: (2011)

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models
por: Smalley, Joshua L., et al.
Publicado: (2015)

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease
por: Guo, Xing, et al.
Publicado: (2016)

Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease
por: Casale, Assunta Maria, et al.
Publicado: (2021)

Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration
por: Estevez-Fraga, Carlos, et al.
Publicado: (2023)

Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research
por: Gupta, Santosh, et al.
Publicado: (2023)

Spontaneous Object Recognition in the Göttingen Minipig
por: Moustgaard, Anette, et al.
Publicado: (2002)

Obstructive sleep apnea in obese minipigs
por: Deng, Meng-Zhao, et al.
Publicado: (2020)

Assessing breed integrity of Göttingen Minipigs
por: Reimer, Christian, et al.
Publicado: (2020)

NASH-inducing Diets in Göttingen Minipigs
por: Pedersen, Henrik D., et al.
Publicado: (2020)

Gradual shortness of breath
por: Alkoteesh, Jamal Al Deen, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_j6902m2q51b569r8m5gmb44fv3