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Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
In Plasmodium falciparum malaria, CD8(+) T cells play a double-edged role. Liver-stage specific CD8(+) T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8(+) T cells, on the other hand, contribute to the development of cerebral malaria in murine mode...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918797/ https://www.ncbi.nlm.nih.gov/pubmed/31921176 http://dx.doi.org/10.3389/fimmu.2019.02917 |
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author | Kaminski, Lea-Christina Riehn, Mathias Abel, Annemieke Steeg, Christiane Yar, Denis Dekugmen Addai-Mensah, Otchere Aminkiah, Francis Owusu Dabo, Ellis Jacobs, Thomas Mackroth, Maria Sophia |
author_facet | Kaminski, Lea-Christina Riehn, Mathias Abel, Annemieke Steeg, Christiane Yar, Denis Dekugmen Addai-Mensah, Otchere Aminkiah, Francis Owusu Dabo, Ellis Jacobs, Thomas Mackroth, Maria Sophia |
author_sort | Kaminski, Lea-Christina |
collection | PubMed |
description | In Plasmodium falciparum malaria, CD8(+) T cells play a double-edged role. Liver-stage specific CD8(+) T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8(+) T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8(+) T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8(+) T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8(+) T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B(+) CD8(+) T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8(+) T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8(+) T cells in the development of malaria complications in humans. |
format | Online Article Text |
id | pubmed-6918797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69187972020-01-09 Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria Kaminski, Lea-Christina Riehn, Mathias Abel, Annemieke Steeg, Christiane Yar, Denis Dekugmen Addai-Mensah, Otchere Aminkiah, Francis Owusu Dabo, Ellis Jacobs, Thomas Mackroth, Maria Sophia Front Immunol Immunology In Plasmodium falciparum malaria, CD8(+) T cells play a double-edged role. Liver-stage specific CD8(+) T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8(+) T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8(+) T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8(+) T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8(+) T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B(+) CD8(+) T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8(+) T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8(+) T cells in the development of malaria complications in humans. Frontiers Media S.A. 2019-12-11 /pmc/articles/PMC6918797/ /pubmed/31921176 http://dx.doi.org/10.3389/fimmu.2019.02917 Text en Copyright © 2019 Kaminski, Riehn, Abel, Steeg, Yar, Addai-Mensah, Aminkiah, Owusu Dabo, Jacobs and Mackroth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kaminski, Lea-Christina Riehn, Mathias Abel, Annemieke Steeg, Christiane Yar, Denis Dekugmen Addai-Mensah, Otchere Aminkiah, Francis Owusu Dabo, Ellis Jacobs, Thomas Mackroth, Maria Sophia Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria |
title | Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria |
title_full | Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria |
title_fullStr | Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria |
title_full_unstemmed | Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria |
title_short | Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria |
title_sort | cytotoxic t cell-derived granzyme b is increased in severe plasmodium falciparum malaria |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918797/ https://www.ncbi.nlm.nih.gov/pubmed/31921176 http://dx.doi.org/10.3389/fimmu.2019.02917 |
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