Cargando…

Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

In Plasmodium falciparum malaria, CD8(+) T cells play a double-edged role. Liver-stage specific CD8(+) T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8(+) T cells, on the other hand, contribute to the development of cerebral malaria in murine mode...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaminski, Lea-Christina, Riehn, Mathias, Abel, Annemieke, Steeg, Christiane, Yar, Denis Dekugmen, Addai-Mensah, Otchere, Aminkiah, Francis, Owusu Dabo, Ellis, Jacobs, Thomas, Mackroth, Maria Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918797/
https://www.ncbi.nlm.nih.gov/pubmed/31921176
http://dx.doi.org/10.3389/fimmu.2019.02917
_version_ 1783480662177611776
author Kaminski, Lea-Christina
Riehn, Mathias
Abel, Annemieke
Steeg, Christiane
Yar, Denis Dekugmen
Addai-Mensah, Otchere
Aminkiah, Francis
Owusu Dabo, Ellis
Jacobs, Thomas
Mackroth, Maria Sophia
author_facet Kaminski, Lea-Christina
Riehn, Mathias
Abel, Annemieke
Steeg, Christiane
Yar, Denis Dekugmen
Addai-Mensah, Otchere
Aminkiah, Francis
Owusu Dabo, Ellis
Jacobs, Thomas
Mackroth, Maria Sophia
author_sort Kaminski, Lea-Christina
collection PubMed
description In Plasmodium falciparum malaria, CD8(+) T cells play a double-edged role. Liver-stage specific CD8(+) T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8(+) T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8(+) T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8(+) T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8(+) T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B(+) CD8(+) T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8(+) T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8(+) T cells in the development of malaria complications in humans.
format Online
Article
Text
id pubmed-6918797
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-69187972020-01-09 Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria Kaminski, Lea-Christina Riehn, Mathias Abel, Annemieke Steeg, Christiane Yar, Denis Dekugmen Addai-Mensah, Otchere Aminkiah, Francis Owusu Dabo, Ellis Jacobs, Thomas Mackroth, Maria Sophia Front Immunol Immunology In Plasmodium falciparum malaria, CD8(+) T cells play a double-edged role. Liver-stage specific CD8(+) T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8(+) T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8(+) T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8(+) T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8(+) T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B(+) CD8(+) T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8(+) T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8(+) T cells in the development of malaria complications in humans. Frontiers Media S.A. 2019-12-11 /pmc/articles/PMC6918797/ /pubmed/31921176 http://dx.doi.org/10.3389/fimmu.2019.02917 Text en Copyright © 2019 Kaminski, Riehn, Abel, Steeg, Yar, Addai-Mensah, Aminkiah, Owusu Dabo, Jacobs and Mackroth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kaminski, Lea-Christina
Riehn, Mathias
Abel, Annemieke
Steeg, Christiane
Yar, Denis Dekugmen
Addai-Mensah, Otchere
Aminkiah, Francis
Owusu Dabo, Ellis
Jacobs, Thomas
Mackroth, Maria Sophia
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
title Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
title_full Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
title_fullStr Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
title_full_unstemmed Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
title_short Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
title_sort cytotoxic t cell-derived granzyme b is increased in severe plasmodium falciparum malaria
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918797/
https://www.ncbi.nlm.nih.gov/pubmed/31921176
http://dx.doi.org/10.3389/fimmu.2019.02917
work_keys_str_mv AT kaminskileachristina cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT riehnmathias cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT abelannemieke cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT steegchristiane cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT yardenisdekugmen cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT addaimensahotchere cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT aminkiahfrancis cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT owusudaboellis cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT jacobsthomas cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria
AT mackrothmariasophia cytotoxictcellderivedgranzymebisincreasedinsevereplasmodiumfalciparummalaria