A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs

BACKGROUND: Inflammatory myopathies are characterized by infiltration of inflammatory cells into muscle. Typically, immune-mediated disorders such as polymyositis, dermatomyositis and inclusion body myositis are diagnosed. OBJECTIVE: A small family of dogs with early onset muscle weakness and inflam...

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Detalles Bibliográficos
Autores principales: Shelton, G. Diane, Minor, Katie M., Li, Kefeng, Naviaux, Jane C., Monk, Jon, Wang, Lin, Guzik, Elizabeth, Guo, Ling T., Porcelli, Vito, Gorgoglione, Ruggiero, Lasorsa, Francesco M., Leegwater, Peter J., Persico, Antonio M., Mickelson, James R., Palmieri, Luigi, Naviaux, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918910/
https://www.ncbi.nlm.nih.gov/pubmed/31594244
http://dx.doi.org/10.3233/JND-190421

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