Cargando…

Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study

BACKGROUND: Tpeak-Tend interval (TpTe), a measurement of transmural dispersion of repolarization (TDR), has been shown to predict ventricular tachyarrhythmia in cardiac resynchronization therapy with defibrillator (CRT-D) patients. However, the ability of TpTe to predict ventricular tachyarrhythmia...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Cong, Hua, Wei, Cai, Chi, Ding, Li-Gang, Niu, Hong-Xia, Fan, Xiao-Han, Liu, Zhi-Min, Gu, Min, Zhao, Yun-Zi, Zhang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919476/
https://www.ncbi.nlm.nih.gov/pubmed/31804316
http://dx.doi.org/10.1097/MD.0000000000018080
_version_ 1783480767040454656
author Xue, Cong
Hua, Wei
Cai, Chi
Ding, Li-Gang
Niu, Hong-Xia
Fan, Xiao-Han
Liu, Zhi-Min
Gu, Min
Zhao, Yun-Zi
Zhang, Shu
author_facet Xue, Cong
Hua, Wei
Cai, Chi
Ding, Li-Gang
Niu, Hong-Xia
Fan, Xiao-Han
Liu, Zhi-Min
Gu, Min
Zhao, Yun-Zi
Zhang, Shu
author_sort Xue, Cong
collection PubMed
description BACKGROUND: Tpeak-Tend interval (TpTe), a measurement of transmural dispersion of repolarization (TDR), has been shown to predict ventricular tachyarrhythmia in cardiac resynchronization therapy with defibrillator (CRT-D) patients. However, the ability of TpTe to predict ventricular tachyarrhythmia and mortality for heart failure patients with a cardioverter-defibrillator (ICD) is not clear. The purpose of this study was to assess the predictive ability of TpTe in heart failure patients with ICD. METHODS AND RESULTS: We enrolled 318 heart failure patients treated after ICD. Patients were divided into 3 groups according to their post-implantation TpTe values and were evaluated every 6 months. The primary endpoint was appropriate ICD therapy. The secondary endpoint was all-cause mortality. During long-term follow-up, the TpTe > 110 ms group (n = 111) experienced more VT/VF episodes (45%) and all-cause mortality (25.2%) than the TpTe 90–110 ms group (n = 109) (26.4%, 14.5%) and TpTe < 90 ms group (n = 98) (11.3%, 11.3%) (overall P < .05, respectively). In Cox regression, longer post-implantation TpTe was associated with an increased number of VT/VF episodes [HR: 1.017; 95% CI: 1.008-1.026; P < .001], all-cause mortality [HR: 1.015; 95% CI: 1.004-1.027; P = .010] and the combined endpoint [HR: 1.018; 95%CI: 1.010-1.026; P < .001]. CONCLUSIONS: Post-implantation TpTe was an independent predictor of both ventricular arrhythmias and all-cause mortality in heart failure patients with an implanted ICD.
format Online
Article
Text
id pubmed-6919476
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-69194762020-01-23 Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study Xue, Cong Hua, Wei Cai, Chi Ding, Li-Gang Niu, Hong-Xia Fan, Xiao-Han Liu, Zhi-Min Gu, Min Zhao, Yun-Zi Zhang, Shu Medicine (Baltimore) 4500 BACKGROUND: Tpeak-Tend interval (TpTe), a measurement of transmural dispersion of repolarization (TDR), has been shown to predict ventricular tachyarrhythmia in cardiac resynchronization therapy with defibrillator (CRT-D) patients. However, the ability of TpTe to predict ventricular tachyarrhythmia and mortality for heart failure patients with a cardioverter-defibrillator (ICD) is not clear. The purpose of this study was to assess the predictive ability of TpTe in heart failure patients with ICD. METHODS AND RESULTS: We enrolled 318 heart failure patients treated after ICD. Patients were divided into 3 groups according to their post-implantation TpTe values and were evaluated every 6 months. The primary endpoint was appropriate ICD therapy. The secondary endpoint was all-cause mortality. During long-term follow-up, the TpTe > 110 ms group (n = 111) experienced more VT/VF episodes (45%) and all-cause mortality (25.2%) than the TpTe 90–110 ms group (n = 109) (26.4%, 14.5%) and TpTe < 90 ms group (n = 98) (11.3%, 11.3%) (overall P < .05, respectively). In Cox regression, longer post-implantation TpTe was associated with an increased number of VT/VF episodes [HR: 1.017; 95% CI: 1.008-1.026; P < .001], all-cause mortality [HR: 1.015; 95% CI: 1.004-1.027; P = .010] and the combined endpoint [HR: 1.018; 95%CI: 1.010-1.026; P < .001]. CONCLUSIONS: Post-implantation TpTe was an independent predictor of both ventricular arrhythmias and all-cause mortality in heart failure patients with an implanted ICD. Wolters Kluwer Health 2019-12-10 /pmc/articles/PMC6919476/ /pubmed/31804316 http://dx.doi.org/10.1097/MD.0000000000018080 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4500
Xue, Cong
Hua, Wei
Cai, Chi
Ding, Li-Gang
Niu, Hong-Xia
Fan, Xiao-Han
Liu, Zhi-Min
Gu, Min
Zhao, Yun-Zi
Zhang, Shu
Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study
title Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study
title_full Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study
title_fullStr Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study
title_full_unstemmed Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study
title_short Predictive value of Tpeak-Tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: A cohort study
title_sort predictive value of tpeak-tend interval for ventricular arrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator: a cohort study
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919476/
https://www.ncbi.nlm.nih.gov/pubmed/31804316
http://dx.doi.org/10.1097/MD.0000000000018080
work_keys_str_mv AT xuecong predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT huawei predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT caichi predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT dingligang predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT niuhongxia predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT fanxiaohan predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT liuzhimin predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT gumin predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT zhaoyunzi predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy
AT zhangshu predictivevalueoftpeaktendintervalforventriculararrhythmiaandmortalityinheartfailurepatientswithanimplantablecardioverterdefibrillatoracohortstudy