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Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study
This study tried to investigate the effects of number of medications and age on antihypertensive medication adherence in a real-world setting using a nationwide representative cohort. We obtained data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) of Korea, which is a s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919523/ https://www.ncbi.nlm.nih.gov/pubmed/31804305 http://dx.doi.org/10.1097/MD.0000000000017825 |
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author | Kim, Seung Jae Kwon, Oh Deog Han, Eunice Bormee Lee, Cheol Min Oh, Seung-Won Joh, Hee-Kyung Oh, Bumjo Kwon, Hyuktae Cho, BeLong Choi, Ho Chun |
author_facet | Kim, Seung Jae Kwon, Oh Deog Han, Eunice Bormee Lee, Cheol Min Oh, Seung-Won Joh, Hee-Kyung Oh, Bumjo Kwon, Hyuktae Cho, BeLong Choi, Ho Chun |
author_sort | Kim, Seung Jae |
collection | PubMed |
description | This study tried to investigate the effects of number of medications and age on antihypertensive medication adherence in a real-world setting using a nationwide representative cohort. We obtained data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) of Korea, which is a sample of 2.2% (N = 1,048,061) of total population (N = 46,605,433). Patients aged 20 years or older (N = 150,550) who took antihypertensive medications for at least 1 year were selected. Medication possession ratio (MPR) was used for measuring adherence. The subjects were divided into 5 subgroups according to total number of medications: 1–2, 3–4, 5–6, 7–8, and 9 or more. The mean age and the mean number of medications were 60.3 ± 12.6 years and 4.1 ± 2.2, respectively. The mean MPR was 80.4 ± 23.9%, and 66.9% (N = 100,645) of total subjects were adherent (MPR ≥ 80%). The overall tendency of antihypertensive medication adherence according to the total number of medications displayed an inverted U-shape with a peak at 3–4 drugs. Adherence consistently increased as the age increased until age 69 and started to decrease from age 70. The proportion of adherent patients (MPR ≥ 80%) according to the total number of medications also showed an inverted U-shape with a peak at 3–4 drugs. When the same number of drugs was taken, the proportion of adherent patients according to age featured an inverted U- shape with a peak at 60 to 69 years. Patients taking 9 or more total drugs had the overall odds ratio (95% CI) of non-adherence (MPR < 80%) with 1.17 (1.11–1.24) compared with those taking 1 to 8 total drugs and the odds ratios in the age subgroups of 40 to 49, 50 to 59, 60 to 69 years were 1.57 (1.31–1.87), 1.21 (1.08–1.36), and 1.14 (1.04–1.25), respectively (P < .05). Association between age, total number of medications, and antihypertensive adherence displayed an inverted U-shape with a peak at 3 to 4 total medications and at age 60 to 69 years. When the total number of drugs was 9 or more, adherence decreased prominently, regardless of age. |
format | Online Article Text |
id | pubmed-6919523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-69195232020-01-23 Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study Kim, Seung Jae Kwon, Oh Deog Han, Eunice Bormee Lee, Cheol Min Oh, Seung-Won Joh, Hee-Kyung Oh, Bumjo Kwon, Hyuktae Cho, BeLong Choi, Ho Chun Medicine (Baltimore) 5300 This study tried to investigate the effects of number of medications and age on antihypertensive medication adherence in a real-world setting using a nationwide representative cohort. We obtained data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) of Korea, which is a sample of 2.2% (N = 1,048,061) of total population (N = 46,605,433). Patients aged 20 years or older (N = 150,550) who took antihypertensive medications for at least 1 year were selected. Medication possession ratio (MPR) was used for measuring adherence. The subjects were divided into 5 subgroups according to total number of medications: 1–2, 3–4, 5–6, 7–8, and 9 or more. The mean age and the mean number of medications were 60.3 ± 12.6 years and 4.1 ± 2.2, respectively. The mean MPR was 80.4 ± 23.9%, and 66.9% (N = 100,645) of total subjects were adherent (MPR ≥ 80%). The overall tendency of antihypertensive medication adherence according to the total number of medications displayed an inverted U-shape with a peak at 3–4 drugs. Adherence consistently increased as the age increased until age 69 and started to decrease from age 70. The proportion of adherent patients (MPR ≥ 80%) according to the total number of medications also showed an inverted U-shape with a peak at 3–4 drugs. When the same number of drugs was taken, the proportion of adherent patients according to age featured an inverted U- shape with a peak at 60 to 69 years. Patients taking 9 or more total drugs had the overall odds ratio (95% CI) of non-adherence (MPR < 80%) with 1.17 (1.11–1.24) compared with those taking 1 to 8 total drugs and the odds ratios in the age subgroups of 40 to 49, 50 to 59, 60 to 69 years were 1.57 (1.31–1.87), 1.21 (1.08–1.36), and 1.14 (1.04–1.25), respectively (P < .05). Association between age, total number of medications, and antihypertensive adherence displayed an inverted U-shape with a peak at 3 to 4 total medications and at age 60 to 69 years. When the total number of drugs was 9 or more, adherence decreased prominently, regardless of age. Wolters Kluwer Health 2019-12-10 /pmc/articles/PMC6919523/ /pubmed/31804305 http://dx.doi.org/10.1097/MD.0000000000017825 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5300 Kim, Seung Jae Kwon, Oh Deog Han, Eunice Bormee Lee, Cheol Min Oh, Seung-Won Joh, Hee-Kyung Oh, Bumjo Kwon, Hyuktae Cho, BeLong Choi, Ho Chun Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study |
title | Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study |
title_full | Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study |
title_fullStr | Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study |
title_full_unstemmed | Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study |
title_short | Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study |
title_sort | impact of number of medications and age on adherence to antihypertensive medications: a nationwide population-based study |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919523/ https://www.ncbi.nlm.nih.gov/pubmed/31804305 http://dx.doi.org/10.1097/MD.0000000000017825 |
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