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Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia
BACKGROUND: FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian populati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919540/ https://www.ncbi.nlm.nih.gov/pubmed/31804351 http://dx.doi.org/10.1097/MD.0000000000018240 |
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author | Chen, Ying Wang, Hanfei Yan, Yunwen Ren, Min Yan, Cunye Wang, Benzhong |
author_facet | Chen, Ying Wang, Hanfei Yan, Yunwen Ren, Min Yan, Cunye Wang, Benzhong |
author_sort | Chen, Ying |
collection | PubMed |
description | BACKGROUND: FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies was performed. MATERIAL AND METHODS: We systematically searched PubMed, Embase, Web of Science, and the Chinese biomedical database (CBM) for papers published until November 1, 2018. Odds ratio (OR) with 95% confidential interval (95%CI) was conducted to evaluate the associations. Statistical analysis was conducted using Stata13.0 software. A total of 8 studies covering 2564 cases and 2633 controls were included. RESULTS: The integrated results suggest the following: For the FAS-1377G/A polymorphism, we only found significant associations for allele G vs allele A (OR = 1.100, 95%CI = 1.004–1.206, P = .040). After stratification by ethnicity, a significant association was observed only for the AA+GA vs GG genotype in East Asian populations (OR = 1.177, 95% CI = 1.010–1.371, P = .037). The association was not found in West Asian populations. For the FAS -670A/G polymorphism, no association with cancer risk was found in any comparison model. Sensitivity analysis suggests that the meta-analysis results obtained after excluding any single study were similar to the original ones, suggesting that the meta-analysis results were not significantly affected by any single study. CONCLUSION: These results indicated that FAS-1377G/A polymorphism may contribute to the increased breast cancer susceptibility and could be a promising target for cancer risk prediction. Further studies are needed to determine if the FAS gene confers a risk of breast cancer in other ethnic groups, such as Africans and Latin Americans. |
format | Online Article Text |
id | pubmed-6919540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-69195402020-01-23 Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia Chen, Ying Wang, Hanfei Yan, Yunwen Ren, Min Yan, Cunye Wang, Benzhong Medicine (Baltimore) 6300 BACKGROUND: FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies was performed. MATERIAL AND METHODS: We systematically searched PubMed, Embase, Web of Science, and the Chinese biomedical database (CBM) for papers published until November 1, 2018. Odds ratio (OR) with 95% confidential interval (95%CI) was conducted to evaluate the associations. Statistical analysis was conducted using Stata13.0 software. A total of 8 studies covering 2564 cases and 2633 controls were included. RESULTS: The integrated results suggest the following: For the FAS-1377G/A polymorphism, we only found significant associations for allele G vs allele A (OR = 1.100, 95%CI = 1.004–1.206, P = .040). After stratification by ethnicity, a significant association was observed only for the AA+GA vs GG genotype in East Asian populations (OR = 1.177, 95% CI = 1.010–1.371, P = .037). The association was not found in West Asian populations. For the FAS -670A/G polymorphism, no association with cancer risk was found in any comparison model. Sensitivity analysis suggests that the meta-analysis results obtained after excluding any single study were similar to the original ones, suggesting that the meta-analysis results were not significantly affected by any single study. CONCLUSION: These results indicated that FAS-1377G/A polymorphism may contribute to the increased breast cancer susceptibility and could be a promising target for cancer risk prediction. Further studies are needed to determine if the FAS gene confers a risk of breast cancer in other ethnic groups, such as Africans and Latin Americans. Wolters Kluwer Health 2019-12-10 /pmc/articles/PMC6919540/ /pubmed/31804351 http://dx.doi.org/10.1097/MD.0000000000018240 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 6300 Chen, Ying Wang, Hanfei Yan, Yunwen Ren, Min Yan, Cunye Wang, Benzhong Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia |
title | Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia |
title_full | Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia |
title_fullStr | Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia |
title_full_unstemmed | Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia |
title_short | Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia |
title_sort | correlation between fas single nucleotide polymorphisms and breast carcinoma susceptibility in asia |
topic | 6300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919540/ https://www.ncbi.nlm.nih.gov/pubmed/31804351 http://dx.doi.org/10.1097/MD.0000000000018240 |
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