Cargando…

Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia

BACKGROUND: FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian populati...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ying, Wang, Hanfei, Yan, Yunwen, Ren, Min, Yan, Cunye, Wang, Benzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919540/
https://www.ncbi.nlm.nih.gov/pubmed/31804351
http://dx.doi.org/10.1097/MD.0000000000018240
_version_ 1783480773344493568
author Chen, Ying
Wang, Hanfei
Yan, Yunwen
Ren, Min
Yan, Cunye
Wang, Benzhong
author_facet Chen, Ying
Wang, Hanfei
Yan, Yunwen
Ren, Min
Yan, Cunye
Wang, Benzhong
author_sort Chen, Ying
collection PubMed
description BACKGROUND: FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies was performed. MATERIAL AND METHODS: We systematically searched PubMed, Embase, Web of Science, and the Chinese biomedical database (CBM) for papers published until November 1, 2018. Odds ratio (OR) with 95% confidential interval (95%CI) was conducted to evaluate the associations. Statistical analysis was conducted using Stata13.0 software. A total of 8 studies covering 2564 cases and 2633 controls were included. RESULTS: The integrated results suggest the following: For the FAS-1377G/A polymorphism, we only found significant associations for allele G vs allele A (OR = 1.100, 95%CI = 1.004–1.206, P = .040). After stratification by ethnicity, a significant association was observed only for the AA+GA vs GG genotype in East Asian populations (OR = 1.177, 95% CI = 1.010–1.371, P = .037). The association was not found in West Asian populations. For the FAS -670A/G polymorphism, no association with cancer risk was found in any comparison model. Sensitivity analysis suggests that the meta-analysis results obtained after excluding any single study were similar to the original ones, suggesting that the meta-analysis results were not significantly affected by any single study. CONCLUSION: These results indicated that FAS-1377G/A polymorphism may contribute to the increased breast cancer susceptibility and could be a promising target for cancer risk prediction. Further studies are needed to determine if the FAS gene confers a risk of breast cancer in other ethnic groups, such as Africans and Latin Americans.
format Online
Article
Text
id pubmed-6919540
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-69195402020-01-23 Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia Chen, Ying Wang, Hanfei Yan, Yunwen Ren, Min Yan, Cunye Wang, Benzhong Medicine (Baltimore) 6300 BACKGROUND: FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies was performed. MATERIAL AND METHODS: We systematically searched PubMed, Embase, Web of Science, and the Chinese biomedical database (CBM) for papers published until November 1, 2018. Odds ratio (OR) with 95% confidential interval (95%CI) was conducted to evaluate the associations. Statistical analysis was conducted using Stata13.0 software. A total of 8 studies covering 2564 cases and 2633 controls were included. RESULTS: The integrated results suggest the following: For the FAS-1377G/A polymorphism, we only found significant associations for allele G vs allele A (OR = 1.100, 95%CI = 1.004–1.206, P = .040). After stratification by ethnicity, a significant association was observed only for the AA+GA vs GG genotype in East Asian populations (OR = 1.177, 95% CI = 1.010–1.371, P = .037). The association was not found in West Asian populations. For the FAS -670A/G polymorphism, no association with cancer risk was found in any comparison model. Sensitivity analysis suggests that the meta-analysis results obtained after excluding any single study were similar to the original ones, suggesting that the meta-analysis results were not significantly affected by any single study. CONCLUSION: These results indicated that FAS-1377G/A polymorphism may contribute to the increased breast cancer susceptibility and could be a promising target for cancer risk prediction. Further studies are needed to determine if the FAS gene confers a risk of breast cancer in other ethnic groups, such as Africans and Latin Americans. Wolters Kluwer Health 2019-12-10 /pmc/articles/PMC6919540/ /pubmed/31804351 http://dx.doi.org/10.1097/MD.0000000000018240 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 6300
Chen, Ying
Wang, Hanfei
Yan, Yunwen
Ren, Min
Yan, Cunye
Wang, Benzhong
Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia
title Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia
title_full Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia
title_fullStr Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia
title_full_unstemmed Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia
title_short Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia
title_sort correlation between fas single nucleotide polymorphisms and breast carcinoma susceptibility in asia
topic 6300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919540/
https://www.ncbi.nlm.nih.gov/pubmed/31804351
http://dx.doi.org/10.1097/MD.0000000000018240
work_keys_str_mv AT chenying correlationbetweenfassinglenucleotidepolymorphismsandbreastcarcinomasusceptibilityinasia
AT wanghanfei correlationbetweenfassinglenucleotidepolymorphismsandbreastcarcinomasusceptibilityinasia
AT yanyunwen correlationbetweenfassinglenucleotidepolymorphismsandbreastcarcinomasusceptibilityinasia
AT renmin correlationbetweenfassinglenucleotidepolymorphismsandbreastcarcinomasusceptibilityinasia
AT yancunye correlationbetweenfassinglenucleotidepolymorphismsandbreastcarcinomasusceptibilityinasia
AT wangbenzhong correlationbetweenfassinglenucleotidepolymorphismsandbreastcarcinomasusceptibilityinasia