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The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

The eukaryotic translation initiation factor 2α (eIF2α) kinase GCN2 is activated by amino acid starvation to elicit a rectifying physiological program known as the Integrated Stress Response (ISR). A role for uncharged tRNAs as activating ligands of yeast GCN2 is supported experimentally. However, m...

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Detalles Bibliográficos
Autores principales:	Harding, Heather P, Ordonez, Adriana, Allen, Felicity, Parts, Leopold, Inglis, Alison J, Williams, Roger L, Ron, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919976/ https://www.ncbi.nlm.nih.gov/pubmed/31749445 http://dx.doi.org/10.7554/eLife.50149

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