Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

FOXO transcription factors are critical regulators of cell homeostasis and steer cell death, differentiation and longevity in mammalian cells. By combined pharmacophore-modeling-based in silico and fluorescence polarization-based screening we identified small molecules that physically interact with...

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Detalles Bibliográficos
Autores principales: Hagenbuchner, Judith, Obsilova, Veronika, Kaserer, Teresa, Kaiser, Nora, Rass, Bettina, Psenakova, Katarina, Docekal, Vojtech, Alblova, Miroslava, Kohoutova, Klara, Schuster, Daniela, Aneichyk, Tatsiana, Vesely, Jan, Obexer, Petra, Obsil, Tomas, Ausserlechner, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919977/
https://www.ncbi.nlm.nih.gov/pubmed/31789593
http://dx.doi.org/10.7554/eLife.48876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919977/
https://www.ncbi.nlm.nih.gov/pubmed/31789593
http://dx.doi.org/10.7554/eLife.48876

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