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Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty
A 57‐year‐old woman with poorly controlled diabetes was admitted to our hospital for additional treatment of severe asthma. Although bronchial thermoplasty was performed in the both upper lobes, cough and dyspnoea gradually appeared 2 weeks later. High‐resolution computed tomography revealed thickne...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920061/ https://www.ncbi.nlm.nih.gov/pubmed/31890213 http://dx.doi.org/10.1002/rcr2.514 |
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author | Otoshi, Ryota Baba, Tomohisa Komatsu, Shigeru Asaoka, Masato Hagiwara, Eri Ogura, Takashi |
author_facet | Otoshi, Ryota Baba, Tomohisa Komatsu, Shigeru Asaoka, Masato Hagiwara, Eri Ogura, Takashi |
author_sort | Otoshi, Ryota |
collection | PubMed |
description | A 57‐year‐old woman with poorly controlled diabetes was admitted to our hospital for additional treatment of severe asthma. Although bronchial thermoplasty was performed in the both upper lobes, cough and dyspnoea gradually appeared 2 weeks later. High‐resolution computed tomography revealed thickness of intralobular septa and a diffuse ground‐glass attenuation in the lung fields. Laboratory examination revealed elevated levels of serum eosinophils and total immunoglobulin E. Bronchoalveolar lavage fluid showed a remarkable increase of eosinophils as high as 48.5%, then eosinophilic pneumonia was diagnosed. Although treatment with steroids resulted in an improvement of eosinophilic pneumonia, the treatment was discontinued after 4 days because it worsened her diabetic condition. Since eosinophilic pneumonia recurred after discontinuing steroid, mepolizumab was administered, which subsequently improved her disease condition. Clinicians should be aware that bronchial thermoplasty can lead to eosinophilic pneumonia and mepolizumab might be an effective treatment in this setting. |
format | Online Article Text |
id | pubmed-6920061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-69200612019-12-30 Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty Otoshi, Ryota Baba, Tomohisa Komatsu, Shigeru Asaoka, Masato Hagiwara, Eri Ogura, Takashi Respirol Case Rep Case Reports A 57‐year‐old woman with poorly controlled diabetes was admitted to our hospital for additional treatment of severe asthma. Although bronchial thermoplasty was performed in the both upper lobes, cough and dyspnoea gradually appeared 2 weeks later. High‐resolution computed tomography revealed thickness of intralobular septa and a diffuse ground‐glass attenuation in the lung fields. Laboratory examination revealed elevated levels of serum eosinophils and total immunoglobulin E. Bronchoalveolar lavage fluid showed a remarkable increase of eosinophils as high as 48.5%, then eosinophilic pneumonia was diagnosed. Although treatment with steroids resulted in an improvement of eosinophilic pneumonia, the treatment was discontinued after 4 days because it worsened her diabetic condition. Since eosinophilic pneumonia recurred after discontinuing steroid, mepolizumab was administered, which subsequently improved her disease condition. Clinicians should be aware that bronchial thermoplasty can lead to eosinophilic pneumonia and mepolizumab might be an effective treatment in this setting. John Wiley & Sons, Ltd 2019-12-18 /pmc/articles/PMC6920061/ /pubmed/31890213 http://dx.doi.org/10.1002/rcr2.514 Text en © 2019 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Reports Otoshi, Ryota Baba, Tomohisa Komatsu, Shigeru Asaoka, Masato Hagiwara, Eri Ogura, Takashi Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty |
title | Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty |
title_full | Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty |
title_fullStr | Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty |
title_full_unstemmed | Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty |
title_short | Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty |
title_sort | effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920061/ https://www.ncbi.nlm.nih.gov/pubmed/31890213 http://dx.doi.org/10.1002/rcr2.514 |
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