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Microtubular Dysfunction and Male Infertility

Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme an...

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Detalles Bibliográficos
Autores principales: Gunes, Sezgin, Sengupta, Pallav, Henkel, Ralf, Alguraigari, Aabed, Sinigaglia, Mariana Marques, Kayal, Malik, Joumah, Ahmad, Agarwal, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Sexual Medicine and Andrology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920067/
https://www.ncbi.nlm.nih.gov/pubmed/30350487
http://dx.doi.org/10.5534/wjmh.180066
Descripción
Sumario:Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.