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Microtubular Dysfunction and Male Infertility
Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Sexual Medicine and Andrology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920067/ https://www.ncbi.nlm.nih.gov/pubmed/30350487 http://dx.doi.org/10.5534/wjmh.180066 |
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author | Gunes, Sezgin Sengupta, Pallav Henkel, Ralf Alguraigari, Aabed Sinigaglia, Mariana Marques Kayal, Malik Joumah, Ahmad Agarwal, Ashok |
author_facet | Gunes, Sezgin Sengupta, Pallav Henkel, Ralf Alguraigari, Aabed Sinigaglia, Mariana Marques Kayal, Malik Joumah, Ahmad Agarwal, Ashok |
author_sort | Gunes, Sezgin |
collection | PubMed |
description | Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction. |
format | Online Article Text |
id | pubmed-6920067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society for Sexual Medicine and Andrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-69200672020-01-01 Microtubular Dysfunction and Male Infertility Gunes, Sezgin Sengupta, Pallav Henkel, Ralf Alguraigari, Aabed Sinigaglia, Mariana Marques Kayal, Malik Joumah, Ahmad Agarwal, Ashok World J Mens Health Review Article Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction. Korean Society for Sexual Medicine and Andrology 2020-01 2018-10-22 /pmc/articles/PMC6920067/ /pubmed/30350487 http://dx.doi.org/10.5534/wjmh.180066 Text en Copyright © 2020 Korean Society for Sexual Medicine and Andrology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gunes, Sezgin Sengupta, Pallav Henkel, Ralf Alguraigari, Aabed Sinigaglia, Mariana Marques Kayal, Malik Joumah, Ahmad Agarwal, Ashok Microtubular Dysfunction and Male Infertility |
title | Microtubular Dysfunction and Male Infertility |
title_full | Microtubular Dysfunction and Male Infertility |
title_fullStr | Microtubular Dysfunction and Male Infertility |
title_full_unstemmed | Microtubular Dysfunction and Male Infertility |
title_short | Microtubular Dysfunction and Male Infertility |
title_sort | microtubular dysfunction and male infertility |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920067/ https://www.ncbi.nlm.nih.gov/pubmed/30350487 http://dx.doi.org/10.5534/wjmh.180066 |
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