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Cupid and Psyche system for the diagnosis and treatment of advanced cancer

In advanced cancer patients, malignant cells invade and disseminate within normal cells and develop resistance to therapy with additional genetic mutations, which makes radical cure very difficult. Precision medicine against advanced cancer is hampered by the lack of systems aimed at multiple target...

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Autores principales: SUGIYAMA, Akira, KAWAMURA, Takeshi, TANAKA, Toshiya, DOI, Hirofumi, YAMASHITA, Takefumi, SHINODA, Keiko, FUJITANI, Hideaki, YAMATSUGU, Kenzo, SHIMIZU, Yohei, TATSUMI, Toshifumi, TAKAHASHI, Kazuki, KANAI, Motomu, MIZOHATA, Eiichi, KAWATO, Tatsuya, DOI, Takefumi, INOUE, Tsuyoshi, KODAMA, Tatsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920082/
https://www.ncbi.nlm.nih.gov/pubmed/31827018
http://dx.doi.org/10.2183/pjab.95.041
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author SUGIYAMA, Akira
KAWAMURA, Takeshi
TANAKA, Toshiya
DOI, Hirofumi
YAMASHITA, Takefumi
SHINODA, Keiko
FUJITANI, Hideaki
YAMATSUGU, Kenzo
SHIMIZU, Yohei
TATSUMI, Toshifumi
TAKAHASHI, Kazuki
KANAI, Motomu
MIZOHATA, Eiichi
KAWATO, Tatsuya
DOI, Takefumi
INOUE, Tsuyoshi
KODAMA, Tatsuhiko
author_facet SUGIYAMA, Akira
KAWAMURA, Takeshi
TANAKA, Toshiya
DOI, Hirofumi
YAMASHITA, Takefumi
SHINODA, Keiko
FUJITANI, Hideaki
YAMATSUGU, Kenzo
SHIMIZU, Yohei
TATSUMI, Toshifumi
TAKAHASHI, Kazuki
KANAI, Motomu
MIZOHATA, Eiichi
KAWATO, Tatsuya
DOI, Takefumi
INOUE, Tsuyoshi
KODAMA, Tatsuhiko
author_sort SUGIYAMA, Akira
collection PubMed
description In advanced cancer patients, malignant cells invade and disseminate within normal cells and develop resistance to therapy with additional genetic mutations, which makes radical cure very difficult. Precision medicine against advanced cancer is hampered by the lack of systems aimed at multiple target molecules within multiple loci. Here, we report the development of a versatile diagnostic and therapeutic system for advanced cancer, named the Cupid and Psyche system. Based on the strong non-covalent interaction of streptavidin and biotin, a low immunogenic mutated streptavidin, Cupid, and a modified artificial biotin, Psyche, have been designed. Cupid can be fused with various single-chain variable fragment antibodies and forms tetramer to recognize cancer cells precisely. Psyche can be conjugated to a wide range of diagnostic and therapeutic agents against malignant cells. The Cupid and Psyche system can be used in pre-targeting therapy as well as photo-immunotherapy effectively in animal models supporting the concept of a system for precision medicine for multiple targets within multiple loci.
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spelling pubmed-69200822019-12-23 Cupid and Psyche system for the diagnosis and treatment of advanced cancer SUGIYAMA, Akira KAWAMURA, Takeshi TANAKA, Toshiya DOI, Hirofumi YAMASHITA, Takefumi SHINODA, Keiko FUJITANI, Hideaki YAMATSUGU, Kenzo SHIMIZU, Yohei TATSUMI, Toshifumi TAKAHASHI, Kazuki KANAI, Motomu MIZOHATA, Eiichi KAWATO, Tatsuya DOI, Takefumi INOUE, Tsuyoshi KODAMA, Tatsuhiko Proc Jpn Acad Ser B Phys Biol Sci Review In advanced cancer patients, malignant cells invade and disseminate within normal cells and develop resistance to therapy with additional genetic mutations, which makes radical cure very difficult. Precision medicine against advanced cancer is hampered by the lack of systems aimed at multiple target molecules within multiple loci. Here, we report the development of a versatile diagnostic and therapeutic system for advanced cancer, named the Cupid and Psyche system. Based on the strong non-covalent interaction of streptavidin and biotin, a low immunogenic mutated streptavidin, Cupid, and a modified artificial biotin, Psyche, have been designed. Cupid can be fused with various single-chain variable fragment antibodies and forms tetramer to recognize cancer cells precisely. Psyche can be conjugated to a wide range of diagnostic and therapeutic agents against malignant cells. The Cupid and Psyche system can be used in pre-targeting therapy as well as photo-immunotherapy effectively in animal models supporting the concept of a system for precision medicine for multiple targets within multiple loci. The Japan Academy 2019-12-11 /pmc/articles/PMC6920082/ /pubmed/31827018 http://dx.doi.org/10.2183/pjab.95.041 Text en © 2019 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
SUGIYAMA, Akira
KAWAMURA, Takeshi
TANAKA, Toshiya
DOI, Hirofumi
YAMASHITA, Takefumi
SHINODA, Keiko
FUJITANI, Hideaki
YAMATSUGU, Kenzo
SHIMIZU, Yohei
TATSUMI, Toshifumi
TAKAHASHI, Kazuki
KANAI, Motomu
MIZOHATA, Eiichi
KAWATO, Tatsuya
DOI, Takefumi
INOUE, Tsuyoshi
KODAMA, Tatsuhiko
Cupid and Psyche system for the diagnosis and treatment of advanced cancer
title Cupid and Psyche system for the diagnosis and treatment of advanced cancer
title_full Cupid and Psyche system for the diagnosis and treatment of advanced cancer
title_fullStr Cupid and Psyche system for the diagnosis and treatment of advanced cancer
title_full_unstemmed Cupid and Psyche system for the diagnosis and treatment of advanced cancer
title_short Cupid and Psyche system for the diagnosis and treatment of advanced cancer
title_sort cupid and psyche system for the diagnosis and treatment of advanced cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920082/
https://www.ncbi.nlm.nih.gov/pubmed/31827018
http://dx.doi.org/10.2183/pjab.95.041
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