Downregulation of the human peripheral myelin protein 22 gene by miR-29a in cellular models of Charcot–Marie–Tooth disease

The majority of hereditary neuropathies are caused by duplication of the peripheral myelin protein 22 (PMP22) gene. Therefore, mechanisms to suppress the expression of the PMP22 gene have high therapeutic significance. Here we asked whether the human PMP22 gene is a target for regulation by microRNA...

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Detalles Bibliográficos
Autores principales: Serfecz, Jacquelyn, Bazick, Hannah, Al Salihi, Mohammed Omar, Turner, Peter, Fields, Christopher, Cruz, Pedro, Renne, Rolf, Notterpek, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920087/
https://www.ncbi.nlm.nih.gov/pubmed/31455873
http://dx.doi.org/10.1038/s41434-019-0098-z

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