Hydrogen peroxide in the ER: A tale of triage

Oxidative protein folding in the endoplasmic reticulum (ER) is a significant source of hydrogen peroxide (H(2)O(2)). For correct protein folding the redox state of the ER must be efficiently regulated. As such, several mechanisms with varying degrees of overlap manage the redox state of the ER. H(2)...

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Detalles Bibliográficos
Autores principales: Rashdan, Nabil A., Pattillo, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920092/
https://www.ncbi.nlm.nih.gov/pubmed/31685402
http://dx.doi.org/10.1016/j.redox.2019.101358
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author Rashdan, Nabil A.
Pattillo, Christopher B.
author_facet Rashdan, Nabil A.
Pattillo, Christopher B.
author_sort Rashdan, Nabil A.
collection PubMed
description Oxidative protein folding in the endoplasmic reticulum (ER) is a significant source of hydrogen peroxide (H(2)O(2)). For correct protein folding the redox state of the ER must be efficiently regulated. As such, several mechanisms with varying degrees of overlap manage the redox state of the ER. H(2)O(2) also functions as a second messenger playing a role in most aspects of cellular physiology and pathology, requiring tight control of the concentration and flux of H(2)O(2). Bestetti et al. have demonstrated a role for Aquaporin 11 in transport of H(2)O(2) out of the ER.
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spelling pubmed-69200922019-12-26 Hydrogen peroxide in the ER: A tale of triage Rashdan, Nabil A. Pattillo, Christopher B. Redox Biol Article Oxidative protein folding in the endoplasmic reticulum (ER) is a significant source of hydrogen peroxide (H(2)O(2)). For correct protein folding the redox state of the ER must be efficiently regulated. As such, several mechanisms with varying degrees of overlap manage the redox state of the ER. H(2)O(2) also functions as a second messenger playing a role in most aspects of cellular physiology and pathology, requiring tight control of the concentration and flux of H(2)O(2). Bestetti et al. have demonstrated a role for Aquaporin 11 in transport of H(2)O(2) out of the ER. Elsevier 2019-10-22 /pmc/articles/PMC6920092/ /pubmed/31685402 http://dx.doi.org/10.1016/j.redox.2019.101358 Text en © 2019 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rashdan, Nabil A.
Pattillo, Christopher B.
Hydrogen peroxide in the ER: A tale of triage
title Hydrogen peroxide in the ER: A tale of triage
title_full Hydrogen peroxide in the ER: A tale of triage
title_fullStr Hydrogen peroxide in the ER: A tale of triage
title_full_unstemmed Hydrogen peroxide in the ER: A tale of triage
title_short Hydrogen peroxide in the ER: A tale of triage
title_sort hydrogen peroxide in the er: a tale of triage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920092/
https://www.ncbi.nlm.nih.gov/pubmed/31685402
http://dx.doi.org/10.1016/j.redox.2019.101358
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