Cargando…

Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes

In recent years, an aberrant gastrointestinal colonization has been found to be associated with an higher risk for postnatal sepsis, necrotizing enterocolitis (NEC) and growth impairment in preterm infants. As a consequence, the reasons of intestinal dysbiosis in this population of newborns have inc...

Descripción completa

Detalles Bibliográficos
Autores principales: Tirone, Chiara, Pezza, Lucilla, Paladini, Angela, Tana, Milena, Aurilia, Claudia, Lio, Alessandra, D'Ippolito, Silvia, Tersigni, Chiara, Posteraro, Brunella, Sanguinetti, Maurizio, Di Simone, Nicoletta, Vento, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920179/
https://www.ncbi.nlm.nih.gov/pubmed/31921169
http://dx.doi.org/10.3389/fimmu.2019.02910
_version_ 1783480893965336576
author Tirone, Chiara
Pezza, Lucilla
Paladini, Angela
Tana, Milena
Aurilia, Claudia
Lio, Alessandra
D'Ippolito, Silvia
Tersigni, Chiara
Posteraro, Brunella
Sanguinetti, Maurizio
Di Simone, Nicoletta
Vento, Giovanni
author_facet Tirone, Chiara
Pezza, Lucilla
Paladini, Angela
Tana, Milena
Aurilia, Claudia
Lio, Alessandra
D'Ippolito, Silvia
Tersigni, Chiara
Posteraro, Brunella
Sanguinetti, Maurizio
Di Simone, Nicoletta
Vento, Giovanni
author_sort Tirone, Chiara
collection PubMed
description In recent years, an aberrant gastrointestinal colonization has been found to be associated with an higher risk for postnatal sepsis, necrotizing enterocolitis (NEC) and growth impairment in preterm infants. As a consequence, the reasons of intestinal dysbiosis in this population of newborns have increasingly become an object of interest. The presence of a link between the gut and lung microbiome's development (gut-lung axis) is emerging, and more data show as a gut-brain cross talking mediated by an inflammatory milieu, may affect the immunity system and influence neonatal outcomes. A revision of the studies which examined gut and lung microbiota in preterm infants and a qualitative analysis of data about characteristic patterns and related outcomes in terms of risk of growing impairment, Necrotizing Enterocolitis (NEC), Bronchopulmonary Dysplasia (BPD), and sepsis have been performed. Microbiota take part in the establishment of the gut barrier and many data suggest its immune-modulator role. Furthermore, the development of the gut and lung microbiome (gut-lung axis) appear to be connected and able to lead to abnormal inflammatory responses which have a key role in the pathogenesis of BPD. Dysbiosis and the gut predominance of facultative anaerobes appear to be crucial to the pathogenesis and subsequently to the prevention of such diseases.
format Online
Article
Text
id pubmed-6920179
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-69201792020-01-09 Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes Tirone, Chiara Pezza, Lucilla Paladini, Angela Tana, Milena Aurilia, Claudia Lio, Alessandra D'Ippolito, Silvia Tersigni, Chiara Posteraro, Brunella Sanguinetti, Maurizio Di Simone, Nicoletta Vento, Giovanni Front Immunol Immunology In recent years, an aberrant gastrointestinal colonization has been found to be associated with an higher risk for postnatal sepsis, necrotizing enterocolitis (NEC) and growth impairment in preterm infants. As a consequence, the reasons of intestinal dysbiosis in this population of newborns have increasingly become an object of interest. The presence of a link between the gut and lung microbiome's development (gut-lung axis) is emerging, and more data show as a gut-brain cross talking mediated by an inflammatory milieu, may affect the immunity system and influence neonatal outcomes. A revision of the studies which examined gut and lung microbiota in preterm infants and a qualitative analysis of data about characteristic patterns and related outcomes in terms of risk of growing impairment, Necrotizing Enterocolitis (NEC), Bronchopulmonary Dysplasia (BPD), and sepsis have been performed. Microbiota take part in the establishment of the gut barrier and many data suggest its immune-modulator role. Furthermore, the development of the gut and lung microbiome (gut-lung axis) appear to be connected and able to lead to abnormal inflammatory responses which have a key role in the pathogenesis of BPD. Dysbiosis and the gut predominance of facultative anaerobes appear to be crucial to the pathogenesis and subsequently to the prevention of such diseases. Frontiers Media S.A. 2019-12-12 /pmc/articles/PMC6920179/ /pubmed/31921169 http://dx.doi.org/10.3389/fimmu.2019.02910 Text en Copyright © 2019 Tirone, Pezza, Paladini, Tana, Aurilia, Lio, D'Ippolito, Tersigni, Posteraro, Sanguinetti, Di Simone and Vento. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tirone, Chiara
Pezza, Lucilla
Paladini, Angela
Tana, Milena
Aurilia, Claudia
Lio, Alessandra
D'Ippolito, Silvia
Tersigni, Chiara
Posteraro, Brunella
Sanguinetti, Maurizio
Di Simone, Nicoletta
Vento, Giovanni
Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes
title Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes
title_full Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes
title_fullStr Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes
title_full_unstemmed Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes
title_short Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes
title_sort gut and lung microbiota in preterm infants: immunological modulation and implication in neonatal outcomes
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920179/
https://www.ncbi.nlm.nih.gov/pubmed/31921169
http://dx.doi.org/10.3389/fimmu.2019.02910
work_keys_str_mv AT tironechiara gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT pezzalucilla gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT paladiniangela gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT tanamilena gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT auriliaclaudia gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT lioalessandra gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT dippolitosilvia gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT tersignichiara gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT posterarobrunella gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT sanguinettimaurizio gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT disimonenicoletta gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes
AT ventogiovanni gutandlungmicrobiotainpreterminfantsimmunologicalmodulationandimplicationinneonataloutcomes