Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis

Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry imaging strategy, involving repeated analysis of tissue sections by DESI MS, in po...

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Detalles Bibliográficos
Autores principales: Dexter, Alex, Steven, Rory T., Patel, Aateka, Dailey, Lea Ann, Taylor, Adam J., Ball, Doug, Klapwijk, Jan, Forbes, Ben, Page, Clive P., Bunch, Josephine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920235/
https://www.ncbi.nlm.nih.gov/pubmed/31776643
http://dx.doi.org/10.1007/s00216-019-02151-z

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