Direct glucosone-based synthesis and HILIC-ESI-MS/MS characterization of N-terminal fructosylated valine and valylhistidine for validation of enzymatic HbA(1c) assays in the diagnosis of diabetes mellitus

Naturally occurring fructosamines are of high clinical significance due to their potential use in diabetes mellitus monitoring (quantification of fructosylated hemoglobin, HbA(1c)) or for the investigation of their reactivity in consecutive reactions and harmfulness towards the organism. Here we rep...

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Detalles Bibliográficos
Autores principales: Gerke, Christoph, Buchholz, Monika, Müller, Holger, Meusinger, Reinhard, Grimmler, Matthias, Metzmann, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Paper in Forefront
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920237/
https://www.ncbi.nlm.nih.gov/pubmed/31754770
http://dx.doi.org/10.1007/s00216-019-02186-2

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