A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy

Ibrutinib has revolutionized the treatment of chronic lymphoid malignancies. Despite its success, ibrutinib has been linked with several reports of invasive fungal infections. We present a case of CNS aspergillosis in a CLL patient on first line ibrutinib therapy. We summarize existing case reports...

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Autores principales: Eichenberger, Emily M., Saullo, Jennifer, Brander, Danielle, Wang, Shih-Hsiu, Perfect, John R., Messina, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920281/
https://www.ncbi.nlm.nih.gov/pubmed/31879587
http://dx.doi.org/10.1016/j.mmcr.2019.12.007
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author Eichenberger, Emily M.
Saullo, Jennifer
Brander, Danielle
Wang, Shih-Hsiu
Perfect, John R.
Messina, Julia A.
author_facet Eichenberger, Emily M.
Saullo, Jennifer
Brander, Danielle
Wang, Shih-Hsiu
Perfect, John R.
Messina, Julia A.
author_sort Eichenberger, Emily M.
collection PubMed
description Ibrutinib has revolutionized the treatment of chronic lymphoid malignancies. Despite its success, ibrutinib has been linked with several reports of invasive fungal infections. We present a case of CNS aspergillosis in a CLL patient on first line ibrutinib therapy. We summarize existing case reports and case series of invasive aspergillosis in patients on ibrutinib, the pathogenesis of invasive aspergillosis, and discuss the clinical controversies regarding anti-fungal prophylaxis in this population.
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spelling pubmed-69202812019-12-26 A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy Eichenberger, Emily M. Saullo, Jennifer Brander, Danielle Wang, Shih-Hsiu Perfect, John R. Messina, Julia A. Med Mycol Case Rep Case Report Ibrutinib has revolutionized the treatment of chronic lymphoid malignancies. Despite its success, ibrutinib has been linked with several reports of invasive fungal infections. We present a case of CNS aspergillosis in a CLL patient on first line ibrutinib therapy. We summarize existing case reports and case series of invasive aspergillosis in patients on ibrutinib, the pathogenesis of invasive aspergillosis, and discuss the clinical controversies regarding anti-fungal prophylaxis in this population. Elsevier 2019-12-05 /pmc/articles/PMC6920281/ /pubmed/31879587 http://dx.doi.org/10.1016/j.mmcr.2019.12.007 Text en © 2019 Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Eichenberger, Emily M.
Saullo, Jennifer
Brander, Danielle
Wang, Shih-Hsiu
Perfect, John R.
Messina, Julia A.
A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy
title A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy
title_full A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy
title_fullStr A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy
title_full_unstemmed A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy
title_short A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy
title_sort case of cns aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920281/
https://www.ncbi.nlm.nih.gov/pubmed/31879587
http://dx.doi.org/10.1016/j.mmcr.2019.12.007
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