Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure

OBJECTIVE: Recently, we observed that the specialized proresolving mediator (SPM) entity resolvin D1 activates lipoxin A(4)/formyl peptide receptor 2 (ALX/FPR2), which facilitates cardiac healing and persistent inflammation is a hallmark of impaired cardiac repair in aging. Splenic leukocyte-directe...

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Detalles Bibliográficos
Autores principales: Tourki, Bochra, Kain, Vasundhara, Pullen, Amanda B., Norris, Paul C., Patel, Nirav, Arora, Pankaj, Leroy, Xavier, Serhan, Charles N., Halade, Ganesh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920298/
https://www.ncbi.nlm.nih.gov/pubmed/31918915
http://dx.doi.org/10.1016/j.molmet.2019.10.008

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