N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells

IFNγ enhances allograft immunogenicity and facilitates T-cell mediated rejection. This may cause interstitial fibrosis and tubular atrophy (IFTA), contributing to chronic allograft loss. We assessed if inhibition of T-cell activation by N-octanoyl dopamine (NOD) impairs adherence of activated T-cell...

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Detalles Bibliográficos
Autores principales: Hofmann, Björn B., Krapp, Nicolas, Li, Yingchun, De La Torre, Carolina, Sol, Marloes, Braun, Jana D., Kolibabka, Matthias, Pallavi, Prama, Krämer, Bernhard K., Yard, Benito A., Kälsch, Anna-Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920350/
https://www.ncbi.nlm.nih.gov/pubmed/31853095
http://dx.doi.org/10.1038/s41598-019-55983-1

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