Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1(+/−) mouse model

Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1(+/−) mice, a model of sporadic Parkinson’s disease. We found that the GM1 oligosaccharide, systemical...

Descripción completa

Detalles Bibliográficos
Autores principales: Chiricozzi, Elena, Mauri, Laura, Lunghi, Giulia, Di Biase, Erika, Fazzari, Maria, Maggioni, Margherita, Valsecchi, Manuela, Prioni, Simona, Loberto, Nicoletta, Pomè, Diego Yuri, Ciampa, Maria Grazia, Fato, Pamela, Verlengia, Gianluca, Cattaneo, Stefano, Assini, Robert, Wu, Gusheng, Alselehdar, Samar, Ledeen, Robert W., Sonnino, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920361/
https://www.ncbi.nlm.nih.gov/pubmed/31852959
http://dx.doi.org/10.1038/s41598-019-55885-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920361/
https://www.ncbi.nlm.nih.gov/pubmed/31852959
http://dx.doi.org/10.1038/s41598-019-55885-2

Ejemplares similares