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Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts

Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survi...

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Autores principales: Wu, Fu-Zong, Kuo, Pei-Lun, Huang, Yi-Luan, Tang, En-Kuei, Chen, Chi-Shen, Wu, Ming-Ting, Lin, Yun-Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920422/
https://www.ncbi.nlm.nih.gov/pubmed/31852960
http://dx.doi.org/10.1038/s41598-019-56025-6
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author Wu, Fu-Zong
Kuo, Pei-Lun
Huang, Yi-Luan
Tang, En-Kuei
Chen, Chi-Shen
Wu, Ming-Ting
Lin, Yun-Pei
author_facet Wu, Fu-Zong
Kuo, Pei-Lun
Huang, Yi-Luan
Tang, En-Kuei
Chen, Chi-Shen
Wu, Ming-Ting
Lin, Yun-Pei
author_sort Wu, Fu-Zong
collection PubMed
description Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survival rate. A retrospective study in which 2883 patients with 2883 lung cancer diagnosed according to the hospital-based lung cancer register database between 2007 and 2017. A comparison was performed in term of clinical characteristics and outcomes of lung cancer between the screened and non-screening patient groups. 2883 subjects were identified (93 screened and 2790 non-screened). Screened group patients were younger (59.91 ± 8.14 versus 67.58 ± 12.95; p < 0.0001), and were more likely to be female than non-screened group (61.3% versus 36.8%; p < 0.0001). The screened group showed significantly better outcomes in overall mortality than the non-screened group (10.75% versus 79.06%; <0.0001). In a Cox proportional hazard model, lung cancer in the screened group proved to be an independent prognostic factor in lung cancer subjects. Our findings point to the improved survival outcome in the screened group and might underline the benefit of low-dose computed tomography (LDCT) screening program in Asian populations with the high prevalence of non–smoking-related lung cancer. Further study aimed at the LDCT mass screening program targeting at light smokers and non-smoker outside of existing screening criteria is warranted.
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spelling pubmed-69204222019-12-20 Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts Wu, Fu-Zong Kuo, Pei-Lun Huang, Yi-Luan Tang, En-Kuei Chen, Chi-Shen Wu, Ming-Ting Lin, Yun-Pei Sci Rep Article Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survival rate. A retrospective study in which 2883 patients with 2883 lung cancer diagnosed according to the hospital-based lung cancer register database between 2007 and 2017. A comparison was performed in term of clinical characteristics and outcomes of lung cancer between the screened and non-screening patient groups. 2883 subjects were identified (93 screened and 2790 non-screened). Screened group patients were younger (59.91 ± 8.14 versus 67.58 ± 12.95; p < 0.0001), and were more likely to be female than non-screened group (61.3% versus 36.8%; p < 0.0001). The screened group showed significantly better outcomes in overall mortality than the non-screened group (10.75% versus 79.06%; <0.0001). In a Cox proportional hazard model, lung cancer in the screened group proved to be an independent prognostic factor in lung cancer subjects. Our findings point to the improved survival outcome in the screened group and might underline the benefit of low-dose computed tomography (LDCT) screening program in Asian populations with the high prevalence of non–smoking-related lung cancer. Further study aimed at the LDCT mass screening program targeting at light smokers and non-smoker outside of existing screening criteria is warranted. Nature Publishing Group UK 2019-12-18 /pmc/articles/PMC6920422/ /pubmed/31852960 http://dx.doi.org/10.1038/s41598-019-56025-6 Text en © The Author(s) 2019, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wu, Fu-Zong
Kuo, Pei-Lun
Huang, Yi-Luan
Tang, En-Kuei
Chen, Chi-Shen
Wu, Ming-Ting
Lin, Yun-Pei
Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts
title Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts
title_full Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts
title_fullStr Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts
title_full_unstemmed Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts
title_short Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts
title_sort differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920422/
https://www.ncbi.nlm.nih.gov/pubmed/31852960
http://dx.doi.org/10.1038/s41598-019-56025-6
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