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Improvement in indices of cellular protection after psychological treatment for social anxiety disorder
Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, G...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920472/ https://www.ncbi.nlm.nih.gov/pubmed/31852887 http://dx.doi.org/10.1038/s41398-019-0668-2 |
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author | Månsson, Kristoffer N. T. Lindqvist, Daniel Yang, Liu L. Svanborg, Cecilia Isung, Josef Nilsonne, Gustav Bergman-Nordgren, Lise El Alaoui, Samir Hedman-Lagerlöf, Erik Kraepelien, Martin Högström, Jens Andersson, Gerhard Boraxbekk, Carl-Johan Fischer, Håkan Lavebratt, Catharina Wolkowitz, Owen M. Furmark, Tomas |
author_facet | Månsson, Kristoffer N. T. Lindqvist, Daniel Yang, Liu L. Svanborg, Cecilia Isung, Josef Nilsonne, Gustav Bergman-Nordgren, Lise El Alaoui, Samir Hedman-Lagerlöf, Erik Kraepelien, Martin Högström, Jens Andersson, Gerhard Boraxbekk, Carl-Johan Fischer, Håkan Lavebratt, Catharina Wolkowitz, Owen M. Furmark, Tomas |
author_sort | Månsson, Kristoffer N. T. |
collection | PubMed |
description | Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen’s d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety. |
format | Online Article Text |
id | pubmed-6920472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69204722019-12-23 Improvement in indices of cellular protection after psychological treatment for social anxiety disorder Månsson, Kristoffer N. T. Lindqvist, Daniel Yang, Liu L. Svanborg, Cecilia Isung, Josef Nilsonne, Gustav Bergman-Nordgren, Lise El Alaoui, Samir Hedman-Lagerlöf, Erik Kraepelien, Martin Högström, Jens Andersson, Gerhard Boraxbekk, Carl-Johan Fischer, Håkan Lavebratt, Catharina Wolkowitz, Owen M. Furmark, Tomas Transl Psychiatry Article Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen’s d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety. Nature Publishing Group UK 2019-12-19 /pmc/articles/PMC6920472/ /pubmed/31852887 http://dx.doi.org/10.1038/s41398-019-0668-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Månsson, Kristoffer N. T. Lindqvist, Daniel Yang, Liu L. Svanborg, Cecilia Isung, Josef Nilsonne, Gustav Bergman-Nordgren, Lise El Alaoui, Samir Hedman-Lagerlöf, Erik Kraepelien, Martin Högström, Jens Andersson, Gerhard Boraxbekk, Carl-Johan Fischer, Håkan Lavebratt, Catharina Wolkowitz, Owen M. Furmark, Tomas Improvement in indices of cellular protection after psychological treatment for social anxiety disorder |
title | Improvement in indices of cellular protection after psychological treatment for social anxiety disorder |
title_full | Improvement in indices of cellular protection after psychological treatment for social anxiety disorder |
title_fullStr | Improvement in indices of cellular protection after psychological treatment for social anxiety disorder |
title_full_unstemmed | Improvement in indices of cellular protection after psychological treatment for social anxiety disorder |
title_short | Improvement in indices of cellular protection after psychological treatment for social anxiety disorder |
title_sort | improvement in indices of cellular protection after psychological treatment for social anxiety disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920472/ https://www.ncbi.nlm.nih.gov/pubmed/31852887 http://dx.doi.org/10.1038/s41398-019-0668-2 |
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