1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase

A series of readily accessible 1-(piperidin-3-yl)thymine amides was designed, synthesised and evaluated as Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors. In line with the modelling results, most inhibitors showed reasonable MtbTMPK inhibitory activity. Compounds 4b and 4i were slightly more p...

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Detalles Bibliográficos
Autores principales: Jian, Yanlin, Risseeuw, Martijn D. P., Froeyen, Mathy, Song, Lijun, Cappoen, Davie, Cos, Paul, Munier-Lehmann, Hélène, van Calenbergh, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920704/
https://www.ncbi.nlm.nih.gov/pubmed/31822127
http://dx.doi.org/10.1080/14756366.2019.1662790

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