Circulating tumor cells and γH2AX as biomarkers for responsiveness to radium-223 in advanced prostate cancer patients

AIM: Radium-223 improves overall survival in patients with metastatic castration-resistant prostate cancer to the bone. Radium-223 causes double-strand DNA breaks and produces γH2AX, a potential biomarker for response. We examined the feasibility of tracking γH2AX positivity and numeration in circul...

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Detalles Bibliográficos
Autores principales: Chatzkel, Jonathan, Mocha, Jesse, Smith, Johnna, Zhou, Jun-Min, Kim, Youngchul, El-Haddad, Ghassan, Zhang, Jingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2019
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920735/
https://www.ncbi.nlm.nih.gov/pubmed/31915536
http://dx.doi.org/10.2144/fsoa-2019-0092

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