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Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and O-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling

Tramadol is a μ-opioid receptor agonist and a monoamine reuptake inhibitor. O-desmethyltramadol (M1), the major active metabolite of tramadol, is produced by CYP2D6. A physiologically-based pharmacokinetic model was developed to predict changes in time-concentration profiles for tramadol and M1 acco...

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Detalles Bibliográficos
Autores principales:	Jeong, Hyeon-Cheol, Bae, Soo Hyeon, Bae, Jung-Woo, Lee, Sooyeun, Kim, Anhye, Jang, Yoojeong, Shin, Kwang-Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920759/ https://www.ncbi.nlm.nih.gov/pubmed/31744222 http://dx.doi.org/10.3390/pharmaceutics11110618

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