Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?

Mitotane is the most effective agent in post-operative treatment of adrenocortical carcinoma. In adults, the starting dose is 2–3 g/day and should be slightly increased to reach the therapeutic index of 14–20 mg/L. This study developed a population PK model for mitotane and to simulate recommended/h...

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Detalles Bibliográficos
Autores principales: Cazaubon, Yoann, Talineau, Yohann, Feliu, Catherine, Konecki, Céline, Russello, Jennifer, Mathieu, Olivier, Djerada, Zoubir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920765/
https://www.ncbi.nlm.nih.gov/pubmed/31683663
http://dx.doi.org/10.3390/pharmaceutics11110566

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