Exploring Biological Activity of 4-Oxo-4H-furo[2,3-h]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15

A series of 5-oxo-5H-furo[3,2-g]chromene-6-carbaldehydes and their hydrazone derivatives were evaluated as potential multi-target-directed ligands in vitro against cholinesterases, β-secretase, cyclooxygenase-2, and lipoxygenase-15 (LOX-15), as well as for free radical-scavenging activities. The mos...

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Detalles Bibliográficos
Autores principales: Mphahlele, Malose J., Agbo, Emmanuel N., Gildenhuys, Samantha, Setshedi, Itumeleng B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920776/
https://www.ncbi.nlm.nih.gov/pubmed/31766252
http://dx.doi.org/10.3390/biom9110736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920776/
https://www.ncbi.nlm.nih.gov/pubmed/31766252
http://dx.doi.org/10.3390/biom9110736

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