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Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes

The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus Cinnamosma (Canellaceae) are commonly used in traditional remedies and known to elicit...

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Autores principales: Inocente, Edna Alfaro, Nguyen, Bao, Manwill, Preston K., Benatrehina, Annecie, Kweka, Eliningaya, Wu, Sijin, Cheng, Xiaolin, Rakotondraibe, L. Harinantenaina, Piermarini, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920793/
https://www.ncbi.nlm.nih.gov/pubmed/31731570
http://dx.doi.org/10.3390/insects10110373
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author Inocente, Edna Alfaro
Nguyen, Bao
Manwill, Preston K.
Benatrehina, Annecie
Kweka, Eliningaya
Wu, Sijin
Cheng, Xiaolin
Rakotondraibe, L. Harinantenaina
Piermarini, Peter M.
author_facet Inocente, Edna Alfaro
Nguyen, Bao
Manwill, Preston K.
Benatrehina, Annecie
Kweka, Eliningaya
Wu, Sijin
Cheng, Xiaolin
Rakotondraibe, L. Harinantenaina
Piermarini, Peter M.
author_sort Inocente, Edna Alfaro
collection PubMed
description The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus Cinnamosma (Canellaceae) are commonly used in traditional remedies and known to elicit antifeedant and toxic effects in insect pests. Here we test the hypothesis that extracts of Cinnamosma sp. enriched in drimane sesquiterpenes are toxic and/or antifeedant to the yellow fever mosquito Aedes aegypti. We show that the bark and root extracts, which contain a higher abundance of drimane sesquiterpenes compared to leaves, were the most efficacious. Screening isolated compounds revealed cinnamodial to be the primary driver of adulticidal activity, whereas cinnamodial, polygodial, cinnafragrin A, and capsicodendrin contributed to the larvicidal activity. Moreover, an abundant lactone (cinnamosmolide) in the root extract synergized the larvicidal effects of cinnamodial. The antifeedant activity of the extracts was primarily contributed to cinnamodial, polygodial, and cinnamolide. Parallel experiments with warburganal isolated from Warburgia ugandensis (Canellaceae) revealed that aldehydes are critical for—and a hydroxyl modulates—insecticidal activity. Our results indicate that plant drimane sesquiterpenes provide valuable chemical platforms for developing insecticides and repellents to control mosquito vectors.
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spelling pubmed-69207932019-12-24 Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes Inocente, Edna Alfaro Nguyen, Bao Manwill, Preston K. Benatrehina, Annecie Kweka, Eliningaya Wu, Sijin Cheng, Xiaolin Rakotondraibe, L. Harinantenaina Piermarini, Peter M. Insects Article The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus Cinnamosma (Canellaceae) are commonly used in traditional remedies and known to elicit antifeedant and toxic effects in insect pests. Here we test the hypothesis that extracts of Cinnamosma sp. enriched in drimane sesquiterpenes are toxic and/or antifeedant to the yellow fever mosquito Aedes aegypti. We show that the bark and root extracts, which contain a higher abundance of drimane sesquiterpenes compared to leaves, were the most efficacious. Screening isolated compounds revealed cinnamodial to be the primary driver of adulticidal activity, whereas cinnamodial, polygodial, cinnafragrin A, and capsicodendrin contributed to the larvicidal activity. Moreover, an abundant lactone (cinnamosmolide) in the root extract synergized the larvicidal effects of cinnamodial. The antifeedant activity of the extracts was primarily contributed to cinnamodial, polygodial, and cinnamolide. Parallel experiments with warburganal isolated from Warburgia ugandensis (Canellaceae) revealed that aldehydes are critical for—and a hydroxyl modulates—insecticidal activity. Our results indicate that plant drimane sesquiterpenes provide valuable chemical platforms for developing insecticides and repellents to control mosquito vectors. MDPI 2019-10-25 /pmc/articles/PMC6920793/ /pubmed/31731570 http://dx.doi.org/10.3390/insects10110373 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Inocente, Edna Alfaro
Nguyen, Bao
Manwill, Preston K.
Benatrehina, Annecie
Kweka, Eliningaya
Wu, Sijin
Cheng, Xiaolin
Rakotondraibe, L. Harinantenaina
Piermarini, Peter M.
Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes
title Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes
title_full Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes
title_fullStr Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes
title_full_unstemmed Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes
title_short Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes
title_sort insecticidal and antifeedant activities of malagasy medicinal plant (cinnamosma sp.) extracts and drimane-type sesquiterpenes against aedes aegypti mosquitoes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920793/
https://www.ncbi.nlm.nih.gov/pubmed/31731570
http://dx.doi.org/10.3390/insects10110373
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