Dithiocarbamate as a Valuable Scaffold for the Inhibition of Metallo-β-Lactmases

The ‘superbug’ infection caused by metallo-β-lactamases (MβLs) has grown into an emergent health threat. Given the clinical importance of MβLs, a novel scaffold, dithiocarbamate, was constructed. The obtained molecules, DC1, DC8 and DC10, inhibited MβLs NDM-1, VIM-2, IMP-1, ImiS and L1 from all thre...

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Detalles Bibliográficos
Autores principales: Ge, Ying, Xu, Li-Wei, Liu, Ya, Sun, Le-Yun, Gao, Han, Li, Jia-Qi, Yang, Kewu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920875/
https://www.ncbi.nlm.nih.gov/pubmed/31694268
http://dx.doi.org/10.3390/biom9110699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920875/
https://www.ncbi.nlm.nih.gov/pubmed/31694268
http://dx.doi.org/10.3390/biom9110699

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