Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies

Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common. Ho...

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Detalles Bibliográficos
Autores principales: Ditzinger, Felix, Price, Daniel J., Nair, Anita, Becker-Baldus, Johanna, Glaubitz, Clemens, Dressman, Jennifer B., Saal, Christoph, Kuentz, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920921/
https://www.ncbi.nlm.nih.gov/pubmed/31689980
http://dx.doi.org/10.3390/pharmaceutics11110577

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