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Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations

Short freeze-drying cycles for biopharmaceuticals are desirable. Formulations containing an amorphous disaccharide, such as sucrose, are prone to collapse upon aggressive primary drying at higher shelf temperature. We used 2-hydroxypropyl-betacyclodextrin (HPBCD) in combination with sucrose and poly...

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Detalles Bibliográficos
Autores principales:	Haeuser, Christina, Goldbach, Pierre, Huwyler, Joerg, Friess, Wolfgang, Allmendinger, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920930/ https://www.ncbi.nlm.nih.gov/pubmed/31744221 http://dx.doi.org/10.3390/pharmaceutics11110616

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