Dynamical Rearrangement of Human Epidermal Growth Factor Receptor 2 upon Antibody Binding: Effects on the Dimerization

Human epidermal growth factor 2 (HER2) is a ligand-free tyrosine kinase receptor of the HER family that is overexpressed in some of the most aggressive tumours. Although it is known that HER2 dimerization involves a specific region of its extracellular domain, the so-called “dimerization arm”, the m...

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Detalles Bibliográficos
Autores principales: R. Magalhães, Pedro, Machuqueiro, Miguel, G. Almeida, José, Melo, André, D. S. Cordeiro, M. Natália, Cabo Verde, Sandra, H. Gümüş, Zeynep, S. Moreira, Irina, D. G. Correia, João, Melo, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920943/
https://www.ncbi.nlm.nih.gov/pubmed/31694351
http://dx.doi.org/10.3390/biom9110706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920943/
https://www.ncbi.nlm.nih.gov/pubmed/31694351
http://dx.doi.org/10.3390/biom9110706

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