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Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood–Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery

Movement of xenobiotic substances across the blood–brain barrier (BBB) is tightly regulated by various transporter proteins, especially the efflux transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). Avoiding drug efflux at the BBB is a unique challenge for the develo...

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Detalles Bibliográficos
Autores principales:	Cui, Yunhai, Lotz, Ralf, Rapp, Hermann, Klinder, Klaus, Himstedt, Anneke, Sauer, Achim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920949/ https://www.ncbi.nlm.nih.gov/pubmed/31718023 http://dx.doi.org/10.3390/pharmaceutics11110595

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