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Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives

Luteolin is a flavonoid often found in various medicinal plants that exhibits multiple biological effects such as antioxidant, anti-inflammatory and immunomodulatory activity. Commercially available medicinal plants and their preparations containing luteolin are often used in the treatment of hypert...

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Autores principales: Juszczak, Aleksandra Maria, Zovko-Končić, Marijana, Tomczyk, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921003/
https://www.ncbi.nlm.nih.gov/pubmed/31726801
http://dx.doi.org/10.3390/biom9110731
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author Juszczak, Aleksandra Maria
Zovko-Končić, Marijana
Tomczyk, Michał
author_facet Juszczak, Aleksandra Maria
Zovko-Končić, Marijana
Tomczyk, Michał
author_sort Juszczak, Aleksandra Maria
collection PubMed
description Luteolin is a flavonoid often found in various medicinal plants that exhibits multiple biological effects such as antioxidant, anti-inflammatory and immunomodulatory activity. Commercially available medicinal plants and their preparations containing luteolin are often used in the treatment of hypertension, inflammatory diseases, and even cancer. However, to establish the quality of such preparations, appropriate analytical methods should be used. Therefore, the present paper provides the first comprehensive review of the current analytical methods that were developed and validated for the quantitative determination of luteolin and its C- and O-derivatives including orientin, isoorientin, luteolin 7-O-glucoside and others. It provides a systematic overview of chromatographic analytical techniques including thin layer chromatography (TLC), high performance thin layer chromatography (HPTLC), liquid chromatography (LC), high performance liquid chromatography (HPLC), gas chromatography (GC) and counter-current chromatography (CCC), as well as the conditions used in the determination of luteolin and its derivatives in plant material.
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spelling pubmed-69210032019-12-24 Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives Juszczak, Aleksandra Maria Zovko-Končić, Marijana Tomczyk, Michał Biomolecules Review Luteolin is a flavonoid often found in various medicinal plants that exhibits multiple biological effects such as antioxidant, anti-inflammatory and immunomodulatory activity. Commercially available medicinal plants and their preparations containing luteolin are often used in the treatment of hypertension, inflammatory diseases, and even cancer. However, to establish the quality of such preparations, appropriate analytical methods should be used. Therefore, the present paper provides the first comprehensive review of the current analytical methods that were developed and validated for the quantitative determination of luteolin and its C- and O-derivatives including orientin, isoorientin, luteolin 7-O-glucoside and others. It provides a systematic overview of chromatographic analytical techniques including thin layer chromatography (TLC), high performance thin layer chromatography (HPTLC), liquid chromatography (LC), high performance liquid chromatography (HPLC), gas chromatography (GC) and counter-current chromatography (CCC), as well as the conditions used in the determination of luteolin and its derivatives in plant material. MDPI 2019-11-12 /pmc/articles/PMC6921003/ /pubmed/31726801 http://dx.doi.org/10.3390/biom9110731 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Juszczak, Aleksandra Maria
Zovko-Končić, Marijana
Tomczyk, Michał
Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
title Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
title_full Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
title_fullStr Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
title_full_unstemmed Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
title_short Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
title_sort recent trends in the application of chromatographic techniques in the analysis of luteolin and its derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921003/
https://www.ncbi.nlm.nih.gov/pubmed/31726801
http://dx.doi.org/10.3390/biom9110731
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