Cargando…
Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia
The TaqI B (rs708272) single-nucleotide variant, i.e., the +279 G/A substitution in intron 1 of the CETP gene, is actively investigated as a risk factor of lipid metabolism disorders. The aim of this study was to analyze the association of rs708272 with lipid parameters and the risk of myocardial in...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921014/ https://www.ncbi.nlm.nih.gov/pubmed/31739638 http://dx.doi.org/10.3390/biom9110739 |
_version_ | 1783481066234839040 |
---|---|
author | Semaev, Sergey Shakhtshneider, Elena Orlov, Pavel Ivanoshchuk, Dinara Malyutina, Sophia Gafarov, Valery Ragino, Yuliya Voevoda, Mikhail |
author_facet | Semaev, Sergey Shakhtshneider, Elena Orlov, Pavel Ivanoshchuk, Dinara Malyutina, Sophia Gafarov, Valery Ragino, Yuliya Voevoda, Mikhail |
author_sort | Semaev, Sergey |
collection | PubMed |
description | The TaqI B (rs708272) single-nucleotide variant, i.e., the +279 G/A substitution in intron 1 of the CETP gene, is actively investigated as a risk factor of lipid metabolism disorders. The aim of this study was to analyze the association of rs708272 with lipid parameters and the risk of myocardial infarction in the population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 participants, >90% white, aged 45–69 years, males: 50%). In total, 3132 randomly selected patients were included. Plasma lipid levels were determined by standard enzymatic assays. Rs708272 was analyzed by RT-PCR via TaqMan single-nucleotide polymorphism (SNP) Genotyping Assays (Thermo Fisher Scientific, USA). The frequencies of rs708272 genotypes AA (homozygote), AG (heterozygote), and GG were 0.21, 0.49, and 0.30, respectively, in this population. Allele A frequency was 0.46. We found an association of allele G with low levels of high-density lipoprotein cholesterol and a high index of atherogenicity in this population (p < 0.001 and p < 0.001, respectively). Allele G was significantly associated with the risk of myocardial infarction among the male participants (odds ratio 1.96, 95% confidence interval 1.208–3.178, p = 0.008) and in the study population (odds ratio 1.465, 95% confidence interval 1.028–2.087, p = 0.036). Thus, rs708272 is associated with myocardial infarction in the white population of Western Siberia (Russia). |
format | Online Article Text |
id | pubmed-6921014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69210142019-12-24 Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia Semaev, Sergey Shakhtshneider, Elena Orlov, Pavel Ivanoshchuk, Dinara Malyutina, Sophia Gafarov, Valery Ragino, Yuliya Voevoda, Mikhail Biomolecules Article The TaqI B (rs708272) single-nucleotide variant, i.e., the +279 G/A substitution in intron 1 of the CETP gene, is actively investigated as a risk factor of lipid metabolism disorders. The aim of this study was to analyze the association of rs708272 with lipid parameters and the risk of myocardial infarction in the population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 participants, >90% white, aged 45–69 years, males: 50%). In total, 3132 randomly selected patients were included. Plasma lipid levels were determined by standard enzymatic assays. Rs708272 was analyzed by RT-PCR via TaqMan single-nucleotide polymorphism (SNP) Genotyping Assays (Thermo Fisher Scientific, USA). The frequencies of rs708272 genotypes AA (homozygote), AG (heterozygote), and GG were 0.21, 0.49, and 0.30, respectively, in this population. Allele A frequency was 0.46. We found an association of allele G with low levels of high-density lipoprotein cholesterol and a high index of atherogenicity in this population (p < 0.001 and p < 0.001, respectively). Allele G was significantly associated with the risk of myocardial infarction among the male participants (odds ratio 1.96, 95% confidence interval 1.208–3.178, p = 0.008) and in the study population (odds ratio 1.465, 95% confidence interval 1.028–2.087, p = 0.036). Thus, rs708272 is associated with myocardial infarction in the white population of Western Siberia (Russia). MDPI 2019-11-14 /pmc/articles/PMC6921014/ /pubmed/31739638 http://dx.doi.org/10.3390/biom9110739 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Semaev, Sergey Shakhtshneider, Elena Orlov, Pavel Ivanoshchuk, Dinara Malyutina, Sophia Gafarov, Valery Ragino, Yuliya Voevoda, Mikhail Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia |
title | Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia |
title_full | Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia |
title_fullStr | Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia |
title_full_unstemmed | Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia |
title_short | Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia |
title_sort | association of rs708272 (cetp gene variant) with lipid profile parameters and the risk of myocardial infarction in the white population of western siberia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921014/ https://www.ncbi.nlm.nih.gov/pubmed/31739638 http://dx.doi.org/10.3390/biom9110739 |
work_keys_str_mv | AT semaevsergey associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia AT shakhtshneiderelena associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia AT orlovpavel associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia AT ivanoshchukdinara associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia AT malyutinasophia associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia AT gafarovvalery associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia AT raginoyuliya associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia AT voevodamikhail associationofrs708272cetpgenevariantwithlipidprofileparametersandtheriskofmyocardialinfarctioninthewhitepopulationofwesternsiberia |