A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

Human NAD(P)H:quinone oxidoreductase 1 (NQO1) is a multi-functional protein whose alteration is associated with cancer, Parkinson’s and Alzheimer´s diseases. NQO1 displays a remarkable functional chemistry, capable of binding different functional ligands that modulate its activity, stability and int...

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Detalles Bibliográficos
Autores principales: Vankova, Pavla, Salido, Eduardo, Timson, David J., Man, Petr, Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921033/
https://www.ncbi.nlm.nih.gov/pubmed/31726777
http://dx.doi.org/10.3390/biom9110728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921033/
https://www.ncbi.nlm.nih.gov/pubmed/31726777
http://dx.doi.org/10.3390/biom9110728

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