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Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway

In our previous work, we designed and implemented a synthetic metabolic pathway for 1,2,3-trichloropropane (TCP) biodegradation in Escherichia coli. Significant effects of metabolic burden and toxicity exacerbation were observed on single cell and population levels. Deeper understanding of mechanism...

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Detalles Bibliográficos
Autores principales:	Demko, Martin, Chrást, Lukáš, Dvořák, Pavel, Damborský, Jiří, Šafránek, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921056/ https://www.ncbi.nlm.nih.gov/pubmed/31718036 http://dx.doi.org/10.3390/microorganisms7110553

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