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Development and Evaluation of Physiologically Based Pharmacokinetic Drug–Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug–disease models by allowing incorporation of relevant pathophysiological changes. The aim of the present work was to explore and identify the differences in rifampicin pharmacokinetics (PK) after the...

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Detalles Bibliográficos
Autores principales:	Rasool, Muhammad F., Khalid, Sundus, Majeed, Abdul, Saeed, Hamid, Imran, Imran, Mohany, Mohamed, Al-Rejaie, Salim S., Alqahtani, Faleh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921057/ https://www.ncbi.nlm.nih.gov/pubmed/31694244 http://dx.doi.org/10.3390/pharmaceutics11110578

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