Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration

BACKGROUND: Plethora of efforts fails to yield a single drug to reverse the pathogenesis of Parkinson's disease (PD) and related α-synucleopathies. METHODS: Using chemical biology, we identified a small molecule inhibitor of c-abl kinase, PD180970 that could potentially clear the toxic protein...

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Detalles Bibliográficos
Autores principales: SN, Suresh, Pandurangi, Janhavi, Murumalla, Ravi, DJ, Vidyadhara, Garimella, Lakshmi, Acharya, Achyuth, Rai, Shashank, Paul, Abhik, Yarreiphang, Haorei, Pillai, Malini S, Giridharan, Mridhula, Clement, James P, Alladi, Phalguni Anand, Saiyed, Taslimarif, Manjithaya, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921191/
https://www.ncbi.nlm.nih.gov/pubmed/31727601
http://dx.doi.org/10.1016/j.ebiom.2019.10.036

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