Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report

We herein report a non-smoking 81-year-old man with advanced synchronous multiple primary lung cancers (SMPLC), containing squamous cell carcinoma with strong programmed death-ligand 1 expression in the middle lobe and adenocarcinoma with epidermal growth factor receptor (EGFR) exon 19 deletion in t...

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Autores principales: Tokuyasu, Hirokazu, Horie, Mika, Ishikawa, Soichiro, Sakai, Hiromitsu, Miura, Hiroshi, Yamasaki, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921201/
https://www.ncbi.nlm.nih.gov/pubmed/31886125
http://dx.doi.org/10.1016/j.rmcr.2019.100976
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author Tokuyasu, Hirokazu
Horie, Mika
Ishikawa, Soichiro
Sakai, Hiromitsu
Miura, Hiroshi
Yamasaki, Akira
author_facet Tokuyasu, Hirokazu
Horie, Mika
Ishikawa, Soichiro
Sakai, Hiromitsu
Miura, Hiroshi
Yamasaki, Akira
author_sort Tokuyasu, Hirokazu
collection PubMed
description We herein report a non-smoking 81-year-old man with advanced synchronous multiple primary lung cancers (SMPLC), containing squamous cell carcinoma with strong programmed death-ligand 1 expression in the middle lobe and adenocarcinoma with epidermal growth factor receptor (EGFR) exon 19 deletion in the lower lobe. Programmed death-1 (PD-1) inhibitors were administered as first-line chemotherapy; however, treatment response was poor response. There have been no reported SMPLC cases similar to this. During treatment, his non-smoking status and EGFR deletion might have been the cause of the patient's poor response to first-line PD-1 inhibitor treatment.
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spelling pubmed-69212012019-12-27 Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report Tokuyasu, Hirokazu Horie, Mika Ishikawa, Soichiro Sakai, Hiromitsu Miura, Hiroshi Yamasaki, Akira Respir Med Case Rep Case Report We herein report a non-smoking 81-year-old man with advanced synchronous multiple primary lung cancers (SMPLC), containing squamous cell carcinoma with strong programmed death-ligand 1 expression in the middle lobe and adenocarcinoma with epidermal growth factor receptor (EGFR) exon 19 deletion in the lower lobe. Programmed death-1 (PD-1) inhibitors were administered as first-line chemotherapy; however, treatment response was poor response. There have been no reported SMPLC cases similar to this. During treatment, his non-smoking status and EGFR deletion might have been the cause of the patient's poor response to first-line PD-1 inhibitor treatment. Elsevier 2019-12-09 /pmc/articles/PMC6921201/ /pubmed/31886125 http://dx.doi.org/10.1016/j.rmcr.2019.100976 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tokuyasu, Hirokazu
Horie, Mika
Ishikawa, Soichiro
Sakai, Hiromitsu
Miura, Hiroshi
Yamasaki, Akira
Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report
title Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report
title_full Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report
title_fullStr Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report
title_full_unstemmed Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report
title_short Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report
title_sort multiple lung cancers including squamous cell carcinoma with strong pd-l1 expression and adenocarcinoma with egfr exon 19 deletion: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921201/
https://www.ncbi.nlm.nih.gov/pubmed/31886125
http://dx.doi.org/10.1016/j.rmcr.2019.100976
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