Pharmacological blockade of PCAF ameliorates osteoarthritis development via dual inhibition of TNF-α-driven inflammation and ER stress

BACKGROUND: Epigenetic mechanisms have been reported to play key roles in osteoarthritis (OA) development. P300/CBP-associated factor (PCAF) is a member of the histone acetyltransferases, which exhibits a strong relationship with endoplasmic reticulum (ER) stress and transcription factor nuclear fac...

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Detalles Bibliográficos
Autores principales: Chen, Deheng, Lu, Di, Liu, Haixiao, Xue, Enxing, Zhang, Yu, Shang, Ping, Pan, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921217/
https://www.ncbi.nlm.nih.gov/pubmed/31735552
http://dx.doi.org/10.1016/j.ebiom.2019.10.054

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