A model system for studying superselective radiotherapy of lymph node metastasis in mice with swollen lymph nodes

Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to >8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effec...

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Detalles Bibliográficos
Autores principales: Kikuchi, Ryohei, Sukhbaatar, Ariunbuyan, Sakamoto, Maya, Mori, Shiro, Kodama, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921225/
https://www.ncbi.nlm.nih.gov/pubmed/31886422
http://dx.doi.org/10.1016/j.ctro.2019.05.002
Descripción
Sumario:Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to >8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effects.

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