Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential

PGC-1α controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential role of PGC-1α in cancer. To investigate how loss of PGC-1α activity in primary...

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Detalles Bibliográficos
Autores principales: Prieto, Ignacio, Alarcón, Carmen Rubio, García-Gómez, Raquel, Berdún, Rebeca, Urgel, Tamara, Portero, Manuel, Pamplona, Reinald, Martínez-Ruiz, Antonio, Ruiz-Sanz, José Ignacio, Ruiz-Larrea, M. Begoña, Jove, Mariona, Cerdán, Sebastián, Monsalve, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921228/
https://www.ncbi.nlm.nih.gov/pubmed/31926622
http://dx.doi.org/10.1016/j.redox.2019.101396

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