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Phase I dose-escalation study to determine the safety, tolerability, preliminary efficacy and pharmacokinetics of an intratumoral injection of tigilanol tiglate (EBC-46)
BACKGROUND: Tigilanol tiglate, a short-chain diterpene ester, is being developed as intratumoral treatment of a broad range of cancers. We conducted the first-in-human study of intratumoral tigilanol tiglate in patients with solid tumors. METHODS: Tigilanol tiglate was administered in a multicentre,...
Autores principales: | Panizza, Benedict J., de Souza, Paul, Cooper, Adam, Roohullah, Aflah, Karapetis, Christos S., Lickliter, Jason D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921293/ https://www.ncbi.nlm.nih.gov/pubmed/31810818 http://dx.doi.org/10.1016/j.ebiom.2019.11.037 |
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