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Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration
The peripheral nerve injuries, representing some of the most common types of traumatic lesions affecting the nervous system, are highly invalidating for the patients besides being a huge social burden. Although peripheral nervous system owns a higher regenerative capacity than does central nervous s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921350/ https://www.ncbi.nlm.nih.gov/pubmed/31571644 http://dx.doi.org/10.4103/1673-5374.266043 |
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author | Pisciotta, Alessandra Bertoni, Laura Vallarola, Antonio Bertani, Giulia Mecugni, Daniela Carnevale, Gianluca |
author_facet | Pisciotta, Alessandra Bertoni, Laura Vallarola, Antonio Bertani, Giulia Mecugni, Daniela Carnevale, Gianluca |
author_sort | Pisciotta, Alessandra |
collection | PubMed |
description | The peripheral nerve injuries, representing some of the most common types of traumatic lesions affecting the nervous system, are highly invalidating for the patients besides being a huge social burden. Although peripheral nervous system owns a higher regenerative capacity than does central nervous system, mostly depending on Schwann cells intervention in injury repair, several factors determine the extent of functional outcome after healing. Based on the injury type, different therapeutic approaches have been investigated so far. Nerve grafting and Schwann cell transplantation have represented the gold standard treatment for peripheral nerve injuries, however these approaches own limitations, such as scarce donor nerve availability and donor site morbidity. Cell based therapies might provide a suitable tool for peripheral nerve regeneration, in fact, the ability of different stem cell types to differentiate towards Schwann cells in combination with the use of different scaffolds have been widely investigated in animal models of peripheral nerve injuries in the last decade. Dental pulp is a promising cell source for regenerative medicine, because of the ease of isolation procedures, stem cell proliferation and multipotency abilities, which are due to the embryological origin from neural crest. In this article we review the literature concerning the application of tooth derived stem cell populations combined with different conduits to peripheral nerve injuries animal models, highlighting their regenerative contribution exerted through either glial differentiation and neuroprotective/neurotrophic effects on the host tissue. |
format | Online Article Text |
id | pubmed-6921350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-69213502019-12-26 Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration Pisciotta, Alessandra Bertoni, Laura Vallarola, Antonio Bertani, Giulia Mecugni, Daniela Carnevale, Gianluca Neural Regen Res Review The peripheral nerve injuries, representing some of the most common types of traumatic lesions affecting the nervous system, are highly invalidating for the patients besides being a huge social burden. Although peripheral nervous system owns a higher regenerative capacity than does central nervous system, mostly depending on Schwann cells intervention in injury repair, several factors determine the extent of functional outcome after healing. Based on the injury type, different therapeutic approaches have been investigated so far. Nerve grafting and Schwann cell transplantation have represented the gold standard treatment for peripheral nerve injuries, however these approaches own limitations, such as scarce donor nerve availability and donor site morbidity. Cell based therapies might provide a suitable tool for peripheral nerve regeneration, in fact, the ability of different stem cell types to differentiate towards Schwann cells in combination with the use of different scaffolds have been widely investigated in animal models of peripheral nerve injuries in the last decade. Dental pulp is a promising cell source for regenerative medicine, because of the ease of isolation procedures, stem cell proliferation and multipotency abilities, which are due to the embryological origin from neural crest. In this article we review the literature concerning the application of tooth derived stem cell populations combined with different conduits to peripheral nerve injuries animal models, highlighting their regenerative contribution exerted through either glial differentiation and neuroprotective/neurotrophic effects on the host tissue. Wolters Kluwer - Medknow 2019-09-26 /pmc/articles/PMC6921350/ /pubmed/31571644 http://dx.doi.org/10.4103/1673-5374.266043 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Pisciotta, Alessandra Bertoni, Laura Vallarola, Antonio Bertani, Giulia Mecugni, Daniela Carnevale, Gianluca Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration |
title | Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration |
title_full | Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration |
title_fullStr | Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration |
title_full_unstemmed | Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration |
title_short | Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration |
title_sort | neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921350/ https://www.ncbi.nlm.nih.gov/pubmed/31571644 http://dx.doi.org/10.4103/1673-5374.266043 |
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