Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons (MNs). It was shown that human astrocytes with mutations in genes associated with ALS, like C9orf72 (C9) or SOD1, reduce survival of MNs. Astrocyte toxicity may be related to their d...

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Detalles Bibliográficos
Autores principales: Birger, Anastasya, Ben-Dor, Israel, Ottolenghi, Miri, Turetsky, Tikva, Gil, Yaniv, Sweetat, Sahar, Perez, Liat, Belzer, Vitali, Casden, Natania, Steiner, Debora, Izrael, Michal, Galun, Eithan, Feldman, Eva, Behar, Oded, Reubinoff, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921360/
https://www.ncbi.nlm.nih.gov/pubmed/31787569
http://dx.doi.org/10.1016/j.ebiom.2019.11.026

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